Article

[Influence of diurnal variation in the size of acute myocardial infarction].

Servicio de Cardiología, Hospital Universitario de Canarias, Tenerife, España.
Medicina Intensiva (impact factor: 1.07). 09/2011; 36(1):11-4. DOI:10.1016/j.medin.2011.07.002 pp.11-4
Source: PubMed

ABSTRACT To evaluate whether the size of acute myocardial infarction (AMI) shows circadian variability.
An observational, prospective study.
A 12-bed coronary care unit.
Consecutive patients diagnosed with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.
The patients were divided into two groups according to the time of onset of AMI symptoms (Group A: 0-12hours, Group B: 12-24hours).
Age, sex, cardiovascular risk factors, coronary anatomy, left ventricular ejection fraction, infarct location, time from onset of symptoms to reperfusion, presence of heart failure upon admission, and peak troponin I value.
A total of 108 patients with a diagnosis of STEMI were included. Patients in group A showed a higher troponin I concentration compared to group B (troponin I: 70.85±16.38 versus 60.90±22.92ng / ml, p=0.003). In the multivariate analysis the onset of AMI between 0-12hours was identified as an independent predictor of infarct size (OR: 1.133, 95%CI 1.012-1.267, p=0.01).
An onset of AMI between 0-12hours results in a significantly larger final size of necrosis compared with any other time of presentation.

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Keywords

0-12hours results
 
12-bed coronary care unit
 
acute myocardial infarction
 
AMI symptoms
 
cardiovascular risk factors
 
circadian variability
 
Consecutive patients
 
coronary anatomy
 
group B
 
heart failure
 
higher troponin
 
independent predictor
 
infarct location
 
infarct size
 
larger final size
 
peak troponin
 
prospective study
 
reperfusion
 
ST-elevation myocardial infarction
 
ventricular ejection fraction
 

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