Article

Effect of cardiac resynchronization therapy on thyroid function.

Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, Turkey.
Clinical Cardiology (impact factor: 2.15). 09/2011; 34(11):703-5. DOI:10.1002/clc.20952 pp.703-5
Source: PubMed

ABSTRACT Heart failure patients frequently have thyroid function abnormalities. Cardiac resynchronization therapy (CRT) is a major treatment for patients with advanced chronic heart failure. We aimed to investigate the effects of CRT on thyroid functions.
CRT improves thyroid functions.
Fifty-seven patients (42 male, 15 female; mean age 58 ± 13 y) undergoing CRT were included in the study. Serum levels of thyroid hormones and echocardiographic parameters were measured before and 6 months after CRT. A response to CRT was defined as a reverse remodeling detected by a relative increase of ≥15% in left ventricular ejection fraction.
The clinical status and functional capacity of the patients in the remodeling group were improved significantly. The mean New York Heart Association class was reduced from 3.2 ± 0.4 to 2.2 ± 0.4 (P<0.001). The free triiodothyronine (fT3) level increased from 2.67 pg/mL to 2.97 pg/mL in the reverse remodeling group (P = 0.005). The fT3/fT4 ratio increased from 1.81 to 2.34 (P = 0.006).
CRT improves fT3 levels and fT3/fT4 ratio, which may play an important role in reverse remodeling.

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Keywords

15 female
 
6 months
 
Cardiac resynchronization therapy
 
chronic heart failure
 
clinical status
 
echocardiographic parameters
 
fT3 levels
 
fT3/fT4 ratio
 
Heart failure patients
 
major treatment
 
mean New York Heart Association class
 
relative increase
 
remodeling group
 
Serum levels
 
thyroid functions
 
thyroid hormones
 
ventricular ejection fraction