Association Between Vitamin D and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies

The Sixth People's Hospital affiliated with Shanghai Jiao Tong University, 600 Yishan Rd, Shanghai 200233, People's Republic of China.
Journal of Clinical Oncology (Impact Factor: 18.43). 08/2011; 29(28):3775-82. DOI: 10.1200/JCO.2011.35.7566
Source: PubMed


To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis.
Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis.
Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89).
Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis.

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    • "Eligible participants were incident cases of stage II adenocarcinoma of the colorectum diagnosed between September 2009 and March 2011; the participants were recruited through the Rapid Case Ascertainment (RCA) division of the North Carolina Central Cancer Registry (NCCCR). The details of participant recruitment, study questionnaires, and data collection are described elsewhere [10]. "
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    ABSTRACT: Purpose: Research suggests patients are motivated to supplement standard cancer care with healthy lifestyle changes. However, few studies have prospectively investigated whether these changes result in positive outcomes. In this study, our objective was to examine the associations between vitamin D supplementation and quality of life (QoL), cancer recurrence, and all-cause mortality in stage II CRC patients following diagnosis. Methods: A total of 453 newly diagnosed patients were enrolled from the North Carolina Central Cancer Registry. Data on demographic variables, treatment, and health behaviors were collected by interview at diagnosis, 12, and 24 months post-diagnosis. QoL was measured using the FACT-C and SF-12 questionnaires. Results: After adjustment for potential confounders, the survivors who used vitamin D supplements had a better CCS score (subscale of FACT-C) over 24 months compared to non-users (β = 1.28; 95 % CI 0.07-2.48). This association persisted among calcium users (β = 2.41; 95 % CI 1.01-3.82), but not in non-users (β = 0.34; 95 % CI -1.45-2.13) (P interaction = 0.09). No association was observed with risk of recurrence or mortality. Conclusions: This suggests that vitamin D supplementation may jointly influence QoL with calcium following diagnosis in CRC survivors. These results also support the notion that clinicians should recommend positive lifestyle changes in conjunction with the standard of care.
    Supportive Care in Cancer 09/2015; DOI:10.1007/s00520-015-2945-9 · 2.36 Impact Factor
    • "This is also consistent with deficient vitamin D levels widely reported for cancer patients versus the general population [39] [40], even after adjusting for age, BMI and season of blood draw for the same geography [41]. Different meta-analysis have linked a higher risk of cancer with lower vitamin D levels, Ma et al. [42] "
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    ABSTRACT: Vitamin D review and supplementation recommendations for women diagnosed with breast or ovary cancer have been defined in the context of bone health and cancer prognosis/risk taking as reference wider cancer patients and postmenopausal women. This specific group has been selected due to its higher osteoporosis risk versus postmenopausal women. Early vitamin D supplementation could help maintain bone health, as well as potentially enhance cancer survival rate. Factors considered for supplementation include daily dose, periodicity, chemical form, administration, and serum levels. Sufficient vitamin D serum levels are recommended to be above 30ng/ml (75nmol/l). Maintenance oral supplementation equivalent to a minimum daily dosage of 800-1000IU (20-25μg) cholecalciferol provided in a daily to monthly bases is preferred, also advised to start with higher dosages when vitamin D serum levels are <10ng/ml (25nmol/l). Calcidiol supplementation is more effective, making it advantageous for cases with very low or difficult to raise vitamin D serum levels. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Critical Reviews in Oncology/Hematology 05/2015; 96(1):91-99. DOI:10.1016/j.critrevonc.2015.05.006 · 4.03 Impact Factor
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    • "It has been estimated that approximately 1 million new cases of colorectal cancer (CRC) with 500,000 CRC-related deaths occur annually (Ma et al., 2011; Siegel et al., 2012). Furthermore , the mortality and morbidity rates of CRC have been rising in recent years (Raine et al., 2010; Siegel et al., 2012); therefore, CRC represents the third most commonly diagnosed malignant carcinoma and is the fourth most frequent cause of mortality from malignant carcinoma (Liu et al., 2011). "
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    ABSTRACT: The impact of complete and incomplete colonic obstruction on the short- and long-term outcomes of malignant colorectal cancer has not yet been elucidated. The aim of this study was to investigate whether there was a difference in the impacts of the 2 types of obstruction on the short- and long-term outcomes of colorectal resection. This study included 224 colorectal cancer patients (162 patients with incomplete obstruction and 62 with complete obstruction) with left-sided malignant colonic obstruction who underwent surgical therapy between February 2007 and September 2012. The short- and long-term outcomes of surgical therapy were analyzed. No significant difference was found between the 2 groups with regard to short-term outcomes such as the curative resection rate (80.86 vs 70.97%, P = 0.109), hospital stay time (24.20 ± 16.01 vs 24.19 ± 12.06, P = 0.999), and the overall and respective complications (32.72 vs 46.77%, P = 0.051). Furthermore, no significant difference was found between the 2 groups with regard to long-term outcomes including the 1-, 3-, and 5-year survival rates (P = 0.089), recurrence rates (P = 0.711), and recurrence-free survival rates (P = 0.440). The 2 types of obstruction, i.e., complete and incomplete left-sided malignant colonic obstruction, had no impact on the short- and long-term outcomes of colorectal resection. Similar therapeutic methods can be used for treating both types of obstruction.
    Genetics and molecular research: GMR 10/2014; 13(3):7965-7978. DOI:10.4238/2014.September.29.10 · 0.78 Impact Factor
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