Coumarin-Cu(II) ensemble-based cyanide sensing chemodosimeter.
ABSTRACT An "ensemble"-based chemodosimeter 1-Cu(II) for cyanide detection is reported. 1-Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. "Off-on" fluorescence change of 1-Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1-Cu(II) for biological application was also performed in HepG2 cells.
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ABSTRACT: A new selective fluorescent sensor for Cu2+ and S2−, 2-hydroxy-N′-((quinolin-2-yl)methylene)benzohydrazide (HL), based on 2-methylquinoline derivative has been designed, synthesized and evaluated. The fluorescence of the sensor HL was quenched by Cu2+ with a 1:1 binding ratio, behaving as an “on–off” type sensor even in the presence of a wide range of biological cations. Once binding with Cu2+, it can display high selectivity for S2−. Among the various anions, only sulfide anion induces the revival of fluorescence of HL, resulting in “off–on” type sensing of sulfide anion. The signal transduction occurs via reversible formation–separation of complex L–Cu and CuS. With the addition of Cu2+, sensor HL give rise to a colorless to yellow color change. The resulting yellow solution switches to colorless immediately upon the addition of S2−; however, no changes were observed in the presence of other anions, including CN−, NO3−, P2O74−, various forms of sulfate, and some other reactive sulfur species (RSS) including SCN−, l-methionine (l-Me) and l-cysteine (l-Cys). Notably, the color change is so distinct that the recycling process can be seen clearly by the naked eye.Sensors and Actuators B Chemical 01/2013; 185:125–131. · 3.84 Impact Factor
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ABSTRACT: The binding behavior of triphenylene based copper ensemble prepared in situ has been investigated toward various anions (F(-), Cl(-), Br(-), I(-), CH(3)COO(-), H(2)PO(4)(-), NO(3)(-), OH(-), ClO(4)(-), CN(-), CO(3)(-) and SO(4)(-)) by UV-vis and fluorescence spectroscopy. Among various anions tested, 1-Cu(2+) ensemble shows selective and sensitive response towards cyanide ions and responds to CN(-) ions even in the presence of bovine serum albumin and in blood serum milieu. Further, as practical application of compound 1, we utilized the TLC strips coated with THF solution of 1 for the solid state detection of copper and cyanide ions.Dalton Transactions 08/2012; 41(37):11413-8. · 3.81 Impact Factor
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ABSTRACT: A pyrimidine-naphthalene anchored Schiff base (receptor ) showed Al(3+) selective conformational arrest by inhibition of its C[double bond, length as m-dash]N isomerization (cis-trans) leading to its fluorescent switching in aqueous medium. Nevertheless the H(2)PO(4)(-)/HSO(4)(-) bailed receptor from the Al(3+) arrest leading to its switching 'off'. This conformational arrest and bail of receptor were highly specific as no other ion pairs were able to do the same. The detection limit of the receptor towards Al(3+) is 1.49 × 10(-9) M and is the second highest for the same reported to date in the literature, while the same for H(2)PO(4)(-) and HSO(4)(-) were found to be 2.27 × 10(-7) and 2.91 × 10(-6), respectively. The mechanistic details of 'on-off' switching of the receptor by the analytes have been explored through various spectroscopic studies along with theoretical calculations at density functional theory (DFT) level. The 'on-off' switching of receptor through inputs Al(3+) and H(2)PO(4)(-)/HSO(4)(-) led it to mimic with INH logic function.The Analyst 02/2013; · 4.23 Impact Factor