Chou CL, Chang SC, Lin TC, et al. Differences in clinicopathological characteristics of colorectal cancer between younger and elderly patients: an analysis of 322 patients from a single institution

Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
American journal of surgery (Impact Factor: 2.29). 08/2011; 202(5):574-82. DOI: 10.1016/j.amjsurg.2010.10.014
Source: PubMed


The prognosis of patients with colorectal cancer (CRC) of different onset ages is controversial.
Data were obtained from a prospective database at Taipei Veterans General Hospital. There were 2,738 newly diagnosed patients with CRC from 2001 to 2006. Two extreme age groups, younger (≤40 years) and elderly (≥80 years), were analyzed to compare clinicopathologic characteristics and prognosis after exclusion of specific cancer syndrome.
A total of 322 patients were enrolled in this prospective study. The younger group consisted of 69 patients with mean age of 33.5 years, and the elderly group consisted of 253 patients with mean age of 83.4 years. Younger patients had a higher incidence of mucinous cell type (14.5% vs 6.3%, P = .05), poorly differentiated adenocarcinoma (26.1% vs 6.3%, P < .001), more advanced disease (82.6% vs 41.9%, P < .001), poorer disease-free survival (67.2% vs 79.3%, P = .048), and cancer-specific survival (44.1% vs 73.1%, P < .001) than elderly patients.
In patients with CRC of younger onset, without relevant predisposing risk factors, younger patients have more advanced stages of disease, more aggressive histopathologic characteristics, and poorer prognoses compared with older patients.

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    • "Contradictory to our results, the proportion of patients undergoing emergency surgery was described more than twice as high in the 85 years and above group than in the less than 65 years group [10]. Survival of emergency cases has been shown to be poorer than in those who undergo elective surgery as a result of a higher perioperative mortality rate after emergency surgery (p < 0.001 for our cohort, data not shown) [3, 10, 13]. Differences between studies may be explained, at least in part, by the considerably lower number of patients in our analysis. "
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    International Journal of Colorectal Disease 06/2012; 27(11):1493-9. DOI:10.1007/s00384-012-1514-7 · 2.45 Impact Factor
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