Article

Redefining baseline demographics: the role of genetic testing in hepatitis C virus infection.

Department of Gastroenterology and Hepatology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia.
Clinics in liver disease 08/2011; 15(3):497-513. DOI: 10.1016/j.cld.2011.05.009
Source: PubMed

ABSTRACT The current standard of care for hepatitis C virus (HCV) infection is pegylated interferon and ribavirin. Unfortunately, treatment cures at best only 40% to 50% of patients infected with genotype 1 HCV, the most common HCV genotype in Western countries. Treatment is also expensive and is often poorly tolerated. Therefore, the identification of patients most likely to benefit from treatment is clinically important. Genome-wide association studies have recently identified genetic variants, most notably IL28B and ITPA, which will enhance the ability of clinicians to personalize antiviral therapy for HCV infection.

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