Article

Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction.

Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan. .
Chinese Medicine (Impact Factor: 2.34). 08/2011; 6:32. DOI: 10.1186/1749-8546-6-32
Source: PubMed

ABSTRACT Radix Angelica Sinensis, the dried root of Angelica sinensis (Danggui), is a herb used in Chinese medicine to enrich blood, promote blood circulation and modulate the immune system. It is also used to treat chronic constipation of the elderly and debilitated as well as menstrual disorders. Research has demonstrated that Danggui and its active ingredients, as anti-arthrosclerotic, anti-hypertensive, antioxidant anti-inflammatory agents which would limit platelet aggregation, are effective in reducing the size of cerebral infarction and improving neurological deficit scores.

0 Bookmarks
 · 
252 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two‑herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). The results demonstrated that BHD significantly attenuated learning and spatial memory deficits in the Morris water maze test in a dose‑dependent manner. Transmission electron microscopy observation revealed that the reduction of synapse density in hippocampal CA1 and cortex parietal isolated from rats with 2VO was partially restored by BHD treatment. In addition, the expression levels of a number of antioxidants, including superoxide dismutase, catalase (CAT), glutathine and glutathione peroxidase‑1 (GPx‑1) increased, whereas malondialdehyde decreased in the hippocampi of rats with 2VO following BHD treatment. Polymerase chain reaction and western blot analysis further confirmed that the GPx‑1 and CAT expression increased in the BHD treatment group. In conclusion the results suggested that BHD has therapeutic potential to treat vascular dementia, which may be associated with synapse density and anti‑oxidant activities in the hippocampus.
    Molecular Medicine Reports 06/2014; · 1.48 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Danggui (Radix Angelicae Sinensis) is an herb often used in Traditional Chinese medicine. It is used to promote blood flow and has been used in the treatment of myocardial ischemia-reperfusion injury in animal models. Angiotensin II (Ang II) has been shown to play important roles in mediating cardiovascular diseases, and may cause cardiac hypertrophy and apoptosis. This study aimed to investigate whether Danggui has protective effects on Ang II-induced apoptosis in H9c2 cardiomyoblast cells and study the mechanisms involved.
    BMC Complementary and Alternative Medicine 09/2014; 14(1):358. · 1.88 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Single Chinese herbal medicine is the basic element in traditional Chinese medicine's clinical treatment against disease. Then, it is an interesting and meaningful task to acquire knowledge of a single Chinese herbal medicine within the framework of traditional Chinese medicine (TCM). In this paper, based on the knowledge of TCM, we explored the association rules of Danggui (Angelica sinensis in Latin). These associated rules include Danggui-TCM syndrome/pattern, Danggui-disease, Danggui-symptom, Danggui-TCM herbal formula, and Danggui-Chinese herbal medicines. Through text mining, these rules can be demonstrated in different networks. These associated networks represent a variety of knowledge points and most of them can be validated in textbooks of traditional Chinese medicines. Thus, these results might be useful for both clinical practice and medical research, and the approach provides a novel way in exploring associated rules of single Chinese herbal medicine within the framework of traditional Chinese medicine.
    Software Engineering and Service Science (ICSESS), 2013 4th IEEE International Conference on; 01/2013

Preview (3 Sources)

Download
3 Downloads
Available from