Article

Age and sex-related changes in rat brain mitochondrial oxidative status.

Group of Energy Metabolism and Nutrition, Department of Fundamental Biology and Health Sciences, University Institute of Research on Health Sciences, University of les Illes Balears, Palma de Mallorca, Spain.
Experimental gerontology (impact factor: 3.34). 08/2011; 46(11):923-8. DOI:10.1016/j.exger.2011.08.003 pp.923-8
Source: PubMed

ABSTRACT Mitochondria are the main source of free radical species and the most direct target for their damaging effects, which especially affect the brain mitochondrial function, which is better maintained by females than males. The aim of this work was to investigate the age-related changes in rat brain mitochondrial oxidative status focusing on sex differences. Male and female rat brain from four different age groups (6, 12, 18 and 24 months old) were analyzed. Oxidative damage accumulates in rat brain throughout aging, related to the increasing activity of mitochondrial respiratory chain (MRC) and failure of several antioxidant defenses. The aging effect was less marked in females, which accumulated less oxidative damage than males due in part to their greater antioxidant capacity, such as higher GPx activity and higher UCP5 level. This sexual dimorphism gradually increased during aging.

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Keywords

age-related changes
 
aging effect
 
antioxidant defenses
 
brain mitochondrial function
 
damaging effects
 
different age groups
 
direct target
 
female rat brain
 
free radical species
 
greater antioxidant capacity
 
higher GPx activity
 
higher UCP5 level
 
increasing activity
 
mitochondrial respiratory chain
 
MRC
 
oxidative damage
 
Oxidative damage accumulates
 
rat brain
 
rat brain mitochondrial oxidative status
 
sexual dimorphism