Article

Effect of implantation site and injury condition on host response to human-derived fascia lata ECM in a rat model.

Department of Biomedical Engineering, Orthopaedic Research Center, Lerner Research Institute, ND20, Cleveland Clinic, Cleveland, Ohio, USA.
Journal of Orthopaedic Research (impact factor: 2.81). 08/2011; 30(3):461-7. DOI:10.1002/jor.21529 pp.461-7
Source: PubMed

ABSTRACT The host response and remodeling of ECM scaffolds are believed to be critical determinants of success or failure in repair or reconstructive procedures. Host response has been investigated in subcutaneous or abdominal wall implantation models. The extent to which evaluation of the host response to ECM intended for tendon or ligament repair should be performed in an orthotopic site is not known. This study compared the host response to human-derived fascia lata ECM among various implantation sites in the rat model. Results showed that a xenograft in the rat shoulder does not exhibit a different host response at 7 days from xenograft in the body wall, suggesting that either site may be appropriate to study the early host response to biologic grafts as well as the effect of various treatments aimed to modify the early host response. By 28 days, a xenograft in the rat shoulder does elicit a unique host response from that seen in the body wall. Therefore, it may be more appropriate to use an orthotopic shoulder model for investigating the long-term host response and remodeling of biologic grafts to be used for rotator cuff repair.

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Keywords

abdominal wall implantation models
 
appropriate
 
biologic grafts
 
body wall
 
different host response
 
ECM scaffolds
 
host response
 
human-derived fascia lata ECM
 
long-term host response
 
orthotopic shoulder model
 
orthotopic site
 
rat shoulder
 
reconstructive procedures
 
rotator cuff
 
subcutaneous
 
tendon
 
unique host response
 
various implantation sites
 
various treatments
 
xenograft
 

Diane R Leigh