The effect of genetic factors on the occurrence of myopia.

Damian Czepita, Artur Mojsa, Maria Ustianowska, Maciej Czepita, Ewelina Lachowicz

Department of Ophthalmology, Pomeranian Medical Academy, Szczecin, Poland.

Journal Article: Klinika oczna 01/2011; 113(1-3):22-4.

Abstract

The aim of this study was to investigate on a large population if and how genetic factors have an influence on the occurrence of myopia.
A total of 5533 students were examined (2659 boys and 2874 girls, in age 6 18 years, mean age 11.9, S.D. 3.2). The examination included retinoscopy under cycloplegia induced with 1% tropicamide. Myopia was defined as a spherical equivalent of at least -0.5 dioptres. The students and their parents completed a questionnaire on the child's family history of myopia. Data analysis was performed using chi-squared test; p-values of < 0.05 were considered statistically significant.
It was found that myopia occurs more often in students whose father (p < 0.001), mother (p < 0.001) or siblings (p < 0.0001) have myopia. A relation between the occurrence of myopia in grandparents and grandchildren was not observed (p > 0.05).
The obtained results indicate that genetic factors have a significant effect on the occurrence of myopia.

Source: PubMed

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Keywords

-0.5 dioptres
 
1% tropicamide
 
chi-squared test
 
child's family history
 
cycloplegia induced
 
Data analysis
 
genetic factors
 
grandchildren
 
grandparents
 
large population
 
obtained results
 
parents
 
significant effect
 
spherical equivalent
 
students