Article

The role of microRNAs in viral infection.

School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG72RD, United Kingdom.
Progress in molecular biology and translational science 01/2011; 102:101-39. DOI:10.1016/B978-0-12-415795-8.00002-7 pp.101-39
Source: PubMed

ABSTRACT MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families expressing their own miRNAs, manipulating host miRNA expression, or showing direct or indirect regulation by host or viral miRNAs. In this chapter we will examine the current evidence for interplay between the miRNA pathway and viral infections in mammals.

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Keywords

central regulators
 
different viral families
 
direct
 
indirect regulation
 
interplay
 
manipulating host miRNA expression
 
MicroRNAs
 
miRNA pathway
 
miRNAs
 
numerous pathological
 
own miRNAs
 
recent years
 
viral miRNAs
 

Ashley P E Roberts