Article

Fifteen years of large scale metabolic modeling of yeast: developments and impacts.

Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Biotechnology advances (impact factor: 8.25). 08/2011; 30(5):979-88. DOI:10.1016/j.biotechadv.2011.07.021 pp.979-88
Source: PubMed

ABSTRACT Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies.

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Keywords

applications
 
biological interpretation
 
different areas
 
first large-scale reconstruction
 
metabolic engineering
 
models
 
nine different yeast genome-scale metabolic models
 
novel computational framework
 
Saccharomyces cerevisiae metabolic network 15 years
 
strain improvement
 
yeast metabolic models
 
yeast metabolism