Adiponectin gene and risk of colorectal cancer

Department of Human Genetics, University of Michigan School of Medicine, 1524 BSRB, 109 Zina Pitcher, Ann Arbor, MI, USA.
British Journal of Cancer (Impact Factor: 4.84). 08/2011; 105(4):562-4. DOI: 10.1038/bjc.2011.259
Source: PubMed

ABSTRACT Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity. However, variants of the adiponectin gene (ADIPOQ) have been demonstrated to be inconsistently associated with risk of colorectal cancer.
The current study attempted to evaluate these findings by examining several single nucleotide polymorphisms (SNPs) that were previously genotyped as part of a genome-wide association study in the ADIPOQ gene. Genotyping was also performed for a previously reported risk variant, rs266729, in 1062 individuals with a diagnosis of colorectal cancer and 1062 controls matched on age, gender and ethnicity (Jewish or not Jewish) as part of a population-based case-control study in Israel.
No evidence was found for an association between ADIPOQ and risk of colorectal cancer. The single nucleotide variant previously associated with decreased risk of colorectal cancer, rs266729, revealed an adjusted odds ratio of 1.04; 95% confidence interval, 0.88-1.23.
The SNP, rs266729, was not strongly associated with colorectal cancer in patients of Ashkenazi Jewish descent or other ethnic groups in Israel.

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Available from: Michele C Gornick, Sep 28, 2015
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    • "These data suggest that adiponectin is inversely associated with risk of colorectal cancer and that this association is largely accounted for by non-HMW-adiponectin. Studies that investigated the association between genetic variants at the adiponectin locus and the risk of colorectal cancer reported conflicting results; some studies showed significant associations [84, 85], whereas other studies did not observe any association [86]. "
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