Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans. Nutr J 10:Article 82

Faculty of Physical Therapy, Mahidol University, Thailand.
Nutrition Journal (Impact Factor: 2.64). 08/2011; 10:82. DOI: 10.1186/1475-2891-10-82
Source: PubMed

ABSTRACT It has been known that hypertension is an independent risk factor for cardiovascular disease (CVD). CVD is the major cause of morbidity and mortality in developed and developing countries. Elevation of blood pressure (BP) increases the adverse effect for cardiovascular outcomes. Prevention of increased BP plays a crucial role in a reduction of those outcomes, leading to a decrease in mortality. Therefore, the purpose of this study was to investigate the effects of dietary black sesame meal on BP and oxidative stress in individuals with prehypertension.
Twenty-two women and eight men (aged 49.8 ± 6.6 years) with prehypertension were randomly divided into two groups, 15 subjects per group. They ingested 2.52 g black sesame meal capsules or placebo capsules each day for 4 weeks. Blood samples were obtained after overnight fasting for measurement of plasma lipid, malondialdehyde (MDA) and vitamin E levels. Anthropometry, body composition and BP were measured before and after 4-week administration of black sesame meal or a placebo.
The results showed that 4-week administration of black sesame meal significantly decreased systolic BP (129.3 ± 6.8 vs. 121.0 ± 9.0 mmHg, P < 0.05) and MDA level (1.8 ± 0.6 vs. 1.2 ± 0.6 μmol/L, P < 0.05), and increased vitamin E level (29.4 ± 6.0 vs. 38.2 ± 7.8 μmol/L, P < 0.01). In the black sesame meal group, the change in SBP tended to be positively related to the change in MDA (R = 0.50, P = 0.05), while the change in DBP was negatively related to the change in vitamin E (R = -0.55, P < 0.05). There were no correlations between changes in BP and oxidative stress in the control group.
These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. These data may imply a beneficial effect of black sesame meal on prevention of CVD.

Download full-text


Available from: Natthida Weerapreeyakul, Aug 19, 2015
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Macronutrient and micronutrient deficiencies are very common in the general population, and may be even more common in patients with hypertension and cardiovascular disease due to genetic and environmental causes, and prescription drug use. Vascular biology assumes a pivotal role in the initiation and perpetuation of hypertension and target organ damage sequelae. Endothelial activation, oxidative stress and vascular smooth muscle dysfunction (hypertrophy, hyperplasia and remodeling) are initial events that initiate hypertension. Nutrient-gene interactions determine a broad array of phenotypic consequences such as vascular problems and hypertension. Optimal nutrition, nutraceuticals, vitamins, antioxidants, minerals, weight loss, exercise, smoking cessation, and moderate restriction of alcohol and caffeine, in addition to other lifestyle modifications, can prevent, delay the onset, reduce the severity, treat and control hypertension in many patients. An integrative approach combining these lifestyle suggestions with the correct pharmacologic treatment will best achieve new goal blood pressure levels, reduce cardiovascular risk factors, improve vascular health, reduce target organ damage, including coronary heart disease, stroke, congestive heart failure and renal disease, and reduce healthcare expenditure. The expanded scientific roles for nutraceutical supplements will be discussed in relation to the prevention and treatment of essential hypertension and cardiovascular diseases.
    Expert Review of Cardiovascular Therapy 06/2010; 8(6):821-33. DOI:10.1586/erc.10.63
  • [Show abstract] [Hide abstract]
    ABSTRACT: Sesame is believed to have originated in Africa, and is regarded to be the oldest oilseed crop known to man. Evidence from interspecific hybridization and phytochemical analysis indicate that the progenitor of sesame occurred in the Indian subcontinent (Bedigian et al. 1985). From here, sesame was introduced to Mesopotamia in the Early Bronze Age and by 2000 BC where it became a crop of enormous importance. Mesopotamia became the hub of distribution of sesame into the Mediterranean. By the second century BC, sesame became a prominent oil crop in China. Today sesame is cultivated pantropically.
    Edible Medicinal And Non-Medicinal Plants, 01/2012: pages 187-219; , ISBN: 978-94-007-4052-5
  • [Show abstract] [Hide abstract]
    ABSTRACT: Beyond the well-known effects on blood pressure (BP) of the DASH and the Mediterranean diets, a large number of studies have investigated the possible a BP-lowering effect from different dietary supplements and nutraceuticals, mostly antioxidant agents with a high tolerability and safety profile. In particular, a relatively large body of evidence support the use of potassium, L-arginine, vitamin C, cocoa flavonoids, coenzyme Q10, controlled-release melatonin, and aged garlic extract. However there is a need for data about the long-term safety of a large part of these products. Moreover, further clinical research is advisable to identify between the available active nutraceuticals and those with the best cost-effectiveness and risk-benefit ratio for widespread use in a general population with low added cardiovascular risk related to uncomplicated hypertension.
    Current Hypertension Reports 02/2013; 15(3). DOI:10.1007/s11906-013-0333-8 · 3.90 Impact Factor
Show more