Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials.

Department of Material Science and Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.
Nano Today (Impact Factor: 15). 06/2011; 6(3):309-325. DOI: 10.1016/j.nantod.2011.04.001
Source: PubMed


Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.

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Available from: Darrell J Irvine,
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    • "One alternative strategy that might overcome these targeting limitations is cell-mediated delivery [13] [14]. Certain cell types have the intrinsic ability to cross the endothelial barrier and infiltrate the tumor tissue, which makes them attractive carriers for NP delivery [15]. "

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    • "The targeting approaches described in the following section are categorized as antibody-, genetically-, selectin-, and peptide-directed cell therapies. For further review of cell surface modification strategies see Stephan and Irvine [105]. "
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    • "A number of diverse methods for cell surface engineering have been reported, and a comprehensive review on this topic was recently published [93]. Methods that mimic natural cell surface receptors include a technique termed "protein painting"[94] [95] [96] [97] in which proteins linked to glycoinositol phospholipids are added to cells and become incorporated into cellular plasma membranes. "
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