A PET-MRI case of corticocerebellar diaschisis after stroke.
ABSTRACT We report a case of a 46-year-old man who underwent a hybrid PET-MRI study 3 months after an acute ischemic stroke of the left middle cerebral artery territory. The FDG PET images show a severe hypometabolism occurring in the cortical and subcortical ischemic territory, as well as in functionally connected but intact areas, such as the homolateral pons and the contralateral cerebellar hemisphere. The MRI images show T2 hyperintensity in the pyramidal and frontopontine tract, associated with fiber degeneration, and no significant cerebellar atrophy. Hybrid PET-MRI imaging can measure various correlates (fiber degeneration and metabolic disconnection) of the diaschisis phenomenon.
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ABSTRACT: Magnetic resonance imaging (MRI) is the examination method of choice for the diagnosis of a variety of diseases. MRI allows us to obtain not only anatomical information but also identification of physiological and functional parameters such as networks in the brain and tumor cellularity, which plays an increasing role in oncologic imaging, as well as blood flow and tissue perfusion. However, in many cases such as in epilepsy, degenerative neurological diseases and oncological processes, additional metabolic and molecular information obtained by PET can provide essential complementary information for better diagnosis. The combined information obtained from MRI and PET acquired in a single imaging session allows a more accurate localization of pathological findings and better assessment of the underlying physiopathology, thus providing a more powerful diagnostic tool. Two hundred and twenty-one patients were scanned from April 2011 to January 2012 on a Philips Ingenuity TF PET/MRI system. The purpose of this review article is to provide an overview of the techniques used for the optimization of different protocols performed in our hospital by specialists in the following fields: neuroradiology, head and neck, breast, and prostate imaging. This paper also discusses the different problems encountered, such as the length of studies, motion artifacts, and accuracy of image fusion including physical and technical aspects, and the proposed solutions.MAGMA Magnetic Resonance Materials in Physics Biology and Medicine 09/2012; · 1.88 Impact Factor