Macrophage diversity in cardiac inflammation: A review

The Johns Hopkins University School of Medicine, Training Program in Immunology, USA.
Immunobiology (Impact Factor: 3.04). 06/2011; 217(5):468-75. DOI: 10.1016/j.imbio.2011.06.009
Source: PubMed


Cardiac inflammatory disease represents a significant public health burden, and interesting questions of immunopathologic science and clinical inquiry. Novel insights into the diverse programming and functions within the macrophage lineages in recent years have yielded a view of these cells as dynamic effectors and regulators of immunity, host defense, and inflammatory disease. In this review, we examine and discuss recent investigations into the complex participation of mononuclear phagocytic cells in the pathology of animal models of myocarditis.

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