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[Processes of free radical lipid peroxidation with a particular regard to the role of paraoxonase-1 in the pathogenesis of multiple sclerosis].

Jerzy Berbecki, Krystyna Mitosek-Szewczyk, Jacek Kurzepa, Marcin Nastaj, Katarzyna Łobejko, Zbigniew Stelmasiak

Klinika Neurologii z Pododdziałem Udarowym oraz Wczesnej Rehabilitacji Poudarowej, Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie.

Journal Article: Wiadomości lekarskie (Warsaw, Poland: 1960) 01/2011; 64(1):31-6.

Abstract

Oxidative stress is an imbalance between free radicals production and antioxidant defences. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can attact and demage a variety of critical biological molecules, including lipids, essential cellular proteins and DNA and may be exert in pathogenesis of many disorders. Products of lipid peroxidation can be easily reliably detected in biological fluids and tissues, yielding sensitive and specific signals of lipid peroxidation occurred in vivo. Those products are: isoprostanes (isoP) dimalonealdehyde (MDA), 4-hydroxynonenal (4-HNE). Paraoxonase-1 (PON-1) play a key role in defence of lipid peroxidation. PON-1 is an serum enzyme bound up with high density lipoproteins (HDL). The aim of this work is to discuss the role of oxidative stress in the pathogenesis of multiple sclerosis.

Source: PubMed

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Keywords

4-HNE
 
antioxidant defences
 
biological fluids
 
critical biological molecules
 
demage
 
density lipoproteins
 
essential cellular proteins
 
free radicals production
 
isoprostanes
 
lipid peroxidation
 
lipids
 
MDA
 
multiple sclerosis
 
Oxidative stress
 
pathogenesis
 
PON-1
 
reactive nitrogen species
 
Reactive oxygen species
 
serum enzyme
 
specific signals