Coccidioidomycosis During Pregnancy: A Review and Recommendations for Management

University of California, San Diego, California, USA.
Clinical Infectious Diseases (Impact Factor: 9.42). 08/2011; 53(4):363-8. DOI: 10.1093/cid/cir410
Source: PubMed

ABSTRACT Pregnancy is an established risk factor for the development of severe and disseminated coccidioidomycosis, particularly when infection is acquired during the later stages of gestation. Although recent studies suggest that the incidence of symptomatic coccidioidomycosis during pregnancy is decreasing and that outcome has improved, management is complicated by the observations that azole antifungal agents can be teratogenic when given to some women, particularly at high doses, early in pregnancy. This article summarizes the data on these issues and offers guidance on the management of coccidioidomycosis during pregnancy.

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    • "Abortion due to Coccidioides infection has been reported in two mares [6] [12] and there is only sporadic anecdotal evidence of occurrence in other domestic animals. While pregnancy is considered to be a risk factor for severe disseminated coccidioidomycosis of the mother in humans, fetal or neonatal coccidioidomycosis is uncommon [1] [3] [5]. Reports of human neonatal coccidioidomycosis have suggested that aspiration of infected vaginal secretions during the birth may be the mode of transmission [13] [14]. "
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