Coccidioidomycosis During Pregnancy: A Review and Recommendations for Management
ABSTRACT Pregnancy is an established risk factor for the development of severe and disseminated coccidioidomycosis, particularly when infection is acquired during the later stages of gestation. Although recent studies suggest that the incidence of symptomatic coccidioidomycosis during pregnancy is decreasing and that outcome has improved, management is complicated by the observations that azole antifungal agents can be teratogenic when given to some women, particularly at high doses, early in pregnancy. This article summarizes the data on these issues and offers guidance on the management of coccidioidomycosis during pregnancy.
- SourceAvailable from: Suzanne M Johnson
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- "Abortion due to Coccidioides infection has been reported in two mares   and there is only sporadic anecdotal evidence of occurrence in other domestic animals. While pregnancy is considered to be a risk factor for severe disseminated coccidioidomycosis of the mother in humans, fetal or neonatal coccidioidomycosis is uncommon   . Reports of human neonatal coccidioidomycosis have suggested that aspiration of infected vaginal secretions during the birth may be the mode of transmission  . "
ABSTRACT: Coccidioidomycosis is a fungal disease affecting humans and other mammals caused by the soil-dwelling fungi Coccidioides immitis and C. posadasii. Abortion due to Coccidioides spp. infection is rare in domestic animals and transplacental transmission is considered uncommon in women. This report describes a case of placental-fetal infection and abortion in an alpaca with disseminated C. posadasii infection. PCR amplification and DNA sequencing were used to confirm the etiology, C. posadasii, in fetal tissues.12/2013; 2:159–162. DOI:10.1016/j.mmcr.2013.10.002
Article: How I Treat Coccidioidomycosis[Show abstract] [Hide abstract]
ABSTRACT: Coccidioides immitis and C. posadasii are pathogenic dimorphic fungi responsible for causing coccidioidomycosis in the southwestern part of United States. Incidence of this disease continues to rise in endemic areas. Coccidioidomycosis starts as a respiratory illness and in less than 5 % of cases disseminates to other anatomic sites. Patient management requires careful periodic assessment. Some patients require no therapy, while others require antifungal medications for several months, or in some cases, indefinitely. Factors that influence the decision to treat include degree and duration of patient symptoms, radiographic findings, anti-complementary titers, immunosuppression and comorbidites. Cure for disseminated infection appears to be an unreachable goal with current treatments.Current Fungal Infection Reports 03/2012; 7(1). DOI:10.1007/s12281-012-0120-z
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ABSTRACT: The pathogenic role of invasive fungal infections (IFIs) has increased during the past two decades in Latin America and worldwide, and the number of patients at risk has risen dramatically. Working habits and leisure activities have also been a focus of attention by public health officials, as endemic mycoses have provoked a number of outbreaks. An extensive search of medical literature from Latin America suggests that the incidence of IFIs from both endemic and opportunistic fungi has increased. The increase in endemic mycoses is probably related to population changes (migration, tourism, and increased population growth), whereas the increase in opportunistic mycoses may be associated with the greater number of people at risk. In both cases, the early and appropriate use of diagnostic procedures has improved diagnosis and outcome.Current Fungal Infection Reports 03/2012; 6(1):23-34. DOI:10.1007/s12281-011-0081-7