Variability of trabecular microstructure is age-, gender-, race- and anatomic site-dependent and affects stiffness and stress distribution properties of human vertebral cancellous bone

Section of Biomechanics, Bone and Joint Center, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Bone (Impact Factor: 3.97). 07/2011; 49(4):886-94. DOI: 10.1016/j.bone.2011.07.006
Source: PubMed


Cancellous bone microstructure is an important determinant of the mechanical integrity of vertebrae. The numerous microstructural parameters that have been studied extensively are generally represented as a single value obtained as an average over a sample. The range of the intra-sample variability of cancellous microstructure and its effect on the mechanical properties of bone are less well-understood. The objectives of this study were to investigate the extent to which human cancellous bone microstructure within a vertebra i) is related to bone modulus and stress distribution properties and ii) changes along with age, gender and locations thoracic 12 (T12) vs lumbar 1 (L1).

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Available from: David Fyhrie, Mar 28, 2014
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    • "For microstructural analysis, the largest possible cubical volume of interest (VOI) consisting of only the cancellous bone was cropped from the reconstructed images and segmented using an established global thresholding method [44] [45] [46]. The binarized images were then processed with custom-written stereology software [47] [48] to obtain intra-specimen mean (Av) and standard deviation (SD) of bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp). Degree of anisotropy (␮CT.DA) was also obtained using the 3D method of secants [47] [49]. "
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