Article

Effect of Ayurvedic mercury preparation Makaradhwaja on geriatric canine--a preliminary study.

Department of Veterinary Medicine, Ethics and Jurisprudence, West Bengal University of Animal and Fishery Sciences, Kolkata 700 037, India.
Indian journal of experimental biology (Impact Factor: 1.2). 07/2011; 49(7):534-9.
Source: PubMed

ABSTRACT Makaradhwaja, an alchemical Ayurvedic mercury preparation is used as stimulant and vitalizer. Towards veterinary practices, the acceptability, tolerability and toxicity studies were undertaken in geriatric pet dogs aged more than 10 years irrespective of breed and sex for future use. Makaradhwaja (2.5 mg/kg) was used with honey once daily for 30 days. Before and after treatment, blood was collected for hematological studies as well as liver, kidney function and anti-oxidant activity. In control group, honey itself showed no appreciable change whereas, Makaradhwaja lowered neutrophil and total leucocyte count. Serum cholesterol, urea, glucose, alanine amino transferase, aspartate amino transferase, sodium, phosphorus and calcium were decreased. Haemoglobin and serum creatinine were significantly increased. There was appreciable physical, behavioral and body weight change including quality of life. The dose was used in replication of human dose (125 mg/50 kg). Anti-oxidant study showed significant increase of lipid per oxidation in experimental group while the values of ABTS radical cation decolorisation assay although decreased but did not show any significant changes. Decrease of serum urea and increase of serum creatinine could not be explained on single dose response. Different dose study could only explain the optimum dose to be required in canine practices.

0 Bookmarks
 · 
111 Views
  • Ayu. 01/2013; 34(1):2-3.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Lifestyle diseases (LSDs) are those conditions usually attributed to dramatic shifts in the way humans live their lives, and are an object of medical attention and thus the cause of concern. Continuous usage of conventional medicine for these diseases may produce adverse drug reactions and hence an alternative has become the need of the hour. Rasa Shastra has flourished from medieval period, but therapeutic use of Rasa Dravyas is being explored, it is evident with increasing number of publications validating it. Contemporary pharmaceutics also started exploiting the benefits of these novel elements in terms of Metallo-pharmaceutics. This article focuses on the utility of Rasaushadhis and their role in the betterment of the community with special reference to LSDs.
    International Journal of Research in Ayurveda & Pharmacy. 01/2011; 2:1628-1632.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We examined two Ayurvedic Rasayana formulations, claimed to facilitate 'healthy ageing', for their role in neuroprotection in fly models of polyQ (127Q and Huntington's) and Alzheimer's disorders. Our earlier findings showed that dietary supplement of Amalaki Rasayana, a preparation derived from Indian goose-berry fruits, and Rasa-Sindoor, an organo-metallic Bhasma prepared from mercury and sulphur, improves general well-being of fruit flies. Here we show that dietary supplement of either of these formu-lations during larval period substantially suppressed neurodegeneration in fly models of polyQ and Alz-heimer's disorders without any side-effects. Dietary Amalaki Rasayana or Rasa-Sindoor prevented accu-mulation of inclusion bodies and heat shock proteins, suppressed apoptosis, elevated the levels of hetero-geneous nuclear ribonucleoproteins and cAMP re-sponse element binding protein and at the same time improved the ubiquitin–proteasomal system for better protein clearance in affected cells. Our studies sug-gest, the potential of these Ayurvedic formulations in providing a holistic relief from the increasingly com-mon neurodegenerative disorders. WITH improved healthcare and general hygiene and con-sequent longer life, the societal burden of the various late onset neurodegenerative diseases has substantially increased in recent times. Some of the inherited neurode-generative diseases, known as codon reiteration disorders, are associated with a unique class of dynamic mutations which increase the number of trinucleotide repeats in cer-tain genes beyond the gene-specific normal and stable threshold 1–3 . Several of these codon reiteration neuro-degenerative disorders, which include Huntington's dis-ease (HD) and several spinocerebellar ataxias (SCA), are grouped together as polyQ expansion disorders since they result from expansion of CAG repeats coding for poly-glutamine (polyQ) tracts. Alzheimer's disease (AD), the other common form of senile dementia in humans, is associated with truncated A peptides produced by aber-rant proteolytic cleavage of the transmembrane receptor amyloid precursor protein (APP) 3–5 . A characteristic fea-ture of these neurodegenerative diseases is the accumula-tion of protein aggregates, formed either by the repeat expanded or the truncated protein. AD patients 3–5 show presence of amyloid plaques formed by Ab peptides and tau protein filament tangles in affected neuronal cells, while polyQ inclusion bodies (IB) are seen in polyQ dis-orders like HD and many of the SCAs 1–6 . The amyloid plaques or the polyQ IBs disrupt cellular homeostasis because a variety of critical cellular proteins like molecu-lar chaperones, transcription factors, proteasome subunits and cytoskeletal components get sequestered with the IBs, which directly or indirectly cause cellular damage and consequent death of the target neuronal cells 1–6 . Therefore, these diseases are proteinopathies resulting primarily from a failure of the protein quality control mechanisms of the cell. With a view to understand the molecular and cellular pathophysiology of neurodegeneration and to discover potential drug targets for therapeutic applications, several human neurodegenerative diseases like HD, different SCAs, AD, etc. have been modelled in yeast, Caenorha-bditis, Drosophila and mouse model systems 1,2,5–7 . The Drosophila models offer many advantages because of the powerful genetic resources available in this organism 1 . Such studies have indeed helped in a better understanding of these neurodegenerative disorders and suggested several therapeutic approaches, although therapies that provide holistic relief with little side-effects continue to remain elusive. Several traditional Ayurvedic formulations claim to facilitate 'healthy ageing' 8 and thus have the potential to mitigate the suffering from neurodegenerative diseases 9 . Although Ayurveda, the traditional medicine system of India, has been widely practised for several thousand years, very few systematic studies have been carried out to understand Ayurvedic formulations and practices in terms of contemporary science. With a view to fill this gap, we established Drosophila as a powerful model for
    Current science 12/2013; 105:1711-1723. · 0.91 Impact Factor

Full-text

View
1 Download
Available from