Article

Differential Neural Responses to Food Images in Women with Bulimia versus Anorexia Nervosa

Department of Neuroscience, Uppsala University, Uppsala, Sweden.
PLoS ONE (Impact Factor: 3.23). 07/2011; 6(7):e22259. DOI: 10.1371/journal.pone.0022259
Source: PubMed

ABSTRACT Previous fMRI studies show that women with eating disorders (ED) have differential neural activation to viewing food images. However, despite clinical differences in their responses to food, differential neural activation to thinking about eating food, between women with anorexia nervosa (AN) and bulimia nervosa (BN) is not known.
We compare 50 women (8 with BN, 18 with AN and 24 age-matched healthy controls [HC]) while they view food images during functional Magnetic Resonance Imaging (fMRI).
In response to food (vs non-food) images, women with BN showed greater neural activation in the visual cortex, right dorsolateral prefrontal cortex, right insular cortex and precentral gyrus, women with AN showed greater activation in the right dorsolateral prefrontal cortex, cerebellum and right precuneus. HC women activated the cerebellum, right insular cortex, right medial temporal lobe and left caudate. Direct comparisons revealed that compared to HC, the BN group showed relative deactivation in the bilateral superior temporal gyrus/insula, and visual cortex, and compared to AN had relative deactivation in the parietal lobe and dorsal posterior cingulate cortex, but greater activation in the caudate, superior temporal gyrus, right insula and supplementary motor area.
Women with AN and BN activate top-down cognitive control in response to food images, yet women with BN have increased activation in reward and somatosensory regions, which might impinge on cognitive control over food consumption and binge eating.

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    • "AN is associated with a myriad of physical and psychological comorbidities, high levels of mortality and disability [1]. Significant advances have been made over the last decade in our understanding of the neural correlates of AN, with research highlighting both structural [9] [25] [37]; and functional [6] [30] [34] [39] alterations in the brain. These neuroimaging studies reveal gray and white matter alterations, and disturbances in limbic, frontal and parietal areas, in addition to alterations in the functioning of neurotransmitters including serotonin and dopamine at different stages of AN. "
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    Restorative neurology and neuroscience 09/2014; DOI:10.3233/RNN-140392 · 4.18 Impact Factor
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    • "AN is associated with a myriad of physical and psychological comorbidities, high levels of mortality and disability [1]. Significant advances have been made over the last decade in our understanding of the neural correlates of AN, with research highlighting both structural [9] [25] [37]; and functional [6] [30] [34] [39] alterations in the brain. These neuroimaging studies reveal gray and white matter alterations, and disturbances in limbic, frontal and parietal areas, in addition to alterations in the functioning of neurotransmitters including serotonin and dopamine at different stages of AN. "
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    Neurophysiologie Clinique/Clinical Neurophysiology 09/2014; 44(3). DOI:10.1016/j.neucli.2014.08.002 · 1.46 Impact Factor
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    • "R compared to controls , whereas Kim et al . ( 2012 ) reported increased left anterior insula activity in AN , and significant interactions between the right insula and inferior frontal gyrus . However , it must be noted that the studies by Kim et al . ( 2012 ) and Joos et al . ( 2011 ) involved passive viewing of images . In a study undertaken by Brooks et al . ( 2011 ) , the investigators asked participants to imagine they were eating the food in the images presented to them and were using the objects in the control images . Increased activity of the cerebellum , left visual cortex , right DLPFC and parietal lobe was reported in AN - R to food compared to non - food items , and in the bilateral cere"
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