Article

Antiparasitic activity of C-geranyl flavonoids from Mimulus bigelovii.

Department of Pharmacognosy, Tanta University, Egypt.
Phytotherapy Research (impact factor: 2.09). 08/2011; 25(8):1246-9. DOI:10.1002/ptr.3404
Source: PubMed

ABSTRACT Bioactivity-directed fractionation of the MeOH fraction of the extract of Mimulus bigelovii by means of an axenic Leishmania amastigote assay and chromatographic techniques resulted in the isolation of four C-geranyl flavanones, diplacone (1), 3'-O-methyldiplacone (2), 4'-O-methyldiplacone (3), 3'-O-methyldiplacol (4), together with a geranylated flavone, cannflavin A (5). These compounds were separated from M. bigelovii for the first time. All compounds showed moderate antileishmanial activity against axenic Leishmania donovani amastigotes with IC(50) values ranging from 4.8 to 14.6 μg/mL. The compounds were also tested against the related kinetoplastid parasite Trypanosoma brucei brucei and they showed activity with IC(50) values ranging from 1.4 to 7.2 μg/mL.

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Keywords

axenic Leishmania amastigote assay
 
axenic Leishmania donovani amastigotes
 
Bioactivity-directed fractionation
 
C-geranyl flavanones
 
chromatographic techniques
 
compounds
 
geranylated flavone
 
MeOH fraction
 
moderate antileishmanial activity
 
related kinetoplastid parasite Trypanosoma brucei brucei
 

Manar M Salem