Article

Intraobserver and interobserver agreement of volume perfusion CT (VPCT) measurements in patients with lung lesions.

Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
European journal of radiology (impact factor: 2.65). 07/2011; 81(10):2853-9. DOI:10.1016/j.ejrad.2011.06.047 pp.2853-9
Source: PubMed

ABSTRACT To evaluate intraobserver and interobserver agreement of manually encompassed lung lesions for perfusion measurements using volume-perfusion computed tomography (VPCT).
Institutional review board approval and informed consent were obtained. HIPAA guidelines were followed. A 65-s dynamic study was acquired with scan parameters 80 kV, 60 mAs (80 mAs for patients ≥ 70 kg), 128 × 0.6mm collimation. Blood flow (BF), blood volume (BV) and K(trans) parameters were determined by syngo volume perfusion CT body with 88 lesions analyzed retrospectively.
Within-subject coefficients of variation for intraobserver agreement (range 6.59-12.82%) were superior to those for interobserver agreement (range 21.75-38.30%). Size-dependent analysis revealed lower agreements for lesions <4 cm as compared to larger lesions. Additionally, agreements of the upper, middle and lower lung zones were different.
Intraobserver agreement was substantial for VPCT lung cancer perfusion measurements encouraging the use for tumor characterization and therapy response monitoring. Interobserver agreement is limited and unexperienced readers should be trained before using this new method.

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Keywords

65-s dynamic study
 
88 lesions analyzed retrospectively
 
Blood flow
 
blood volume
 
BV
 
Institutional review board approval
 
interobserver agreement
 
Intraobserver agreement
 
lesions <4 cm
 
lower agreements
 
lower lung zones
 
manually encompassed lung lesions
 
scan parameters 80 kV
 
syngo volume perfusion CT body
 
therapy response monitoring
 
tumor characterization
 
unexperienced readers
 
volume-perfusion computed tomography
 
VPCT lung cancer perfusion measurements
 
Within-subject coefficients