[Show abstract][Hide abstract] ABSTRACT: Organic Electrochemical transistors (OECTs) present unique features for their strategic combination with biomedical interfaces, simple and low voltage operation regime and sensing ability in aqueous environment, but they still lack selectivity, so that a significant effort in research is devoted to overcome this limitation. Here, we focus on the diffusion properties of molecular species in the electrolyte, which opportunely analyzed, modeled and compared to experimental data, serve as a simple and direct key factor in the recognition of species during OECT sensing. Specifically, we model the transient behavior of an OECT considering the effect of diffusion of the target species in the electrolyte. In doing so, we develop a general method that can be used to differentiate and distinguish different molecules from a complex mixture, on the basis of their diffusivity and thus mass. More importantly, the model can be realistically used to determine the physical characteristics of the transported species in a solution from a simple fitting procedure. On the basis of the obtained results, we discuss the contribution that our study could bring to OECT architecture to realize a new generation of devices with improved sensitivity, selectivity and reliability.
[Show abstract][Hide abstract] ABSTRACT: We present label-free, in situ monitoring of individual DNA hybridization in microfluidics. By immobilizing molecular sentinel probes on nanoporous gold disks, we demonstrate sensitivity approaching the single-molecule limit via surface-enhanced Raman scattering which provides robust signals without photobleaching for more than an hour. We further demonstrate target concentration as low as 20 pM can be detected within 10 min under diffusion-limited transport.
[Show abstract][Hide abstract] ABSTRACT: The aim of the study is to open a new scope for organic electrochemical transistors based on PEDOT:PSS, a material blend known for its stability and reliability. These devices can leverage molecular electrocatalysis by incorporating small amounts of nano-catalyst during the transistor manufacturing (spin coating). This methodology is very simple to implement using the know-how of nanochemistry and results in efficient enzymatic activity transduction, in this case utilizing choline oxidase and glutamate oxidase.
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