Cardiac Disease in Methylmalonic Acidemia

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
The Journal of pediatrics (Impact Factor: 4.02). 07/2011; 159(5):862-4. DOI: 10.1016/j.jpeds.2011.06.005
Source: PubMed

ABSTRACT Methylmalonic acidemia (MMA) is a heterogeneous disorder, with onset from infancy to adulthood and varying degrees of organ involvement and severity. Cardiac disease is a known lethal complication of other organic acidemias, but has not been associated with MMA. We identified 3 patients with MMA and cardiac disease.

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