Stimulatory effect of components of rose flowers on catalytic activity and mRNA expression of superoxide dismutase and catalase in erythrocytes

The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.
Environmental Toxicology and Pharmacology (Impact Factor: 1.86). 05/2009; 27(3):396-401. DOI: 10.1016/j.etap.2009.01.004
Source: PubMed

ABSTRACT In the present study, two antioxidant components (polysaccharopeptide complex P(1-a) and condensed tannin P(1-b)) from rose (Rosa rugosa) flowers were each incubated with mouse erythrocytes to investigate their effect on erythrocyte superoxide dismutase (SOD), and catalase (CAT) activities. It was found that the activities of Cu, Zn-SOD and CAT were markedly increased after incubation for 3h with rose flower fractions at the concentration of 500μg/ml. Similar changes were also observed in the erythrocyte gene expression of SOD and CAT. These results show that P(1-a) and P(1-b) are effective antioxidants that increase the activity and the gene expression of SOD and CAT in mouse erythrocytes.

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