Pediatric Urinary Tract Infections

Department of Emergency Medicine, Georgetown University Hospital, Washington, DC 20007, USA.
Emergency medicine clinics of North America (Impact Factor: 0.85). 08/2011; 29(3):637-53. DOI: 10.1016/j.emc.2011.04.004
Source: PubMed

ABSTRACT Urinary tract infections (UTIs) in children are commonly seen in the emergency department and pose several challenges to establishing the proper diagnosis and determining management. This article reviews pediatric UTI and addresses epidemiology, diagnosis, treatment, and imaging, and their importance to the practicing emergency medicine provider. Accurate and timely diagnosis of pediatric UTI can prevent short-term complications, such as severe pyelonephritis or sepsis, and long-term sequelae including scarring of the kidneys, hypertension, and ultimately chronic renal insufficiency and need for transplant.

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    ABSTRACT: AimsL-Selenaproline (L-selenazolidine-4-carboxylic acid) is a toxic analogue of L-proline that inhibits the growth of the urinary tract pathogen Escherichia coli in both laboratory culture media and normal human urine. The aim of the present study was to identify the transport systems involved in its uptake.Methods and ResultsDeletion mutants from the Keio collection were tested for their susceptibility to L-selenaproline (SCA) and L-selenocystine (SeCys) on minimal salts agar medium. All single gene mutants were sensitive to both compounds, but double mutants with deletions in fliY and ydjN or in yecS and ydjN were resistant to SCA and SeCys. The YdjN transporter active in strain JW1905 (ΔfliY::kan yecC+yecS+ydjN+) was inhibited by both SCA and SeCys, but the FliY YecS YecC ABC transporter system active in strain JW1718 (fliY+yecC+yecS+ ΔydjN::kan) was best inhibited by these compounds in the presence of dithiothreitol.ConclusionsL-selenaproline and L-selenocystine are accumulated by both the FliY YecC YecS and the YdjN L-cystine transporter systems in E. coli.Significance and Impact of the StudyBecause susceptibility to selenium-containing analogues of L-proline and L-cystine is dependent on multiple transport systems, these compounds may be effective in the treatment of urinary tract infections.This article is protected by copyright. All rights reserved.
    Journal of Applied Microbiology 08/2014; 117(5). DOI:10.1111/jam.12623 · 2.39 Impact Factor
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    ABSTRACT: This cross sectional study was conducted to determine the prevalence of UTI among population visiting Jinnah Hospital Lahore to identify microorganisms responsible for UTI to explore sensitivity patterns of identified microorganisms to certain antibiotics used in the cure of UTI. This study included 378 samples of all age groups. In this study we utilized two main approaches, questionnaire and urine testing (urinalysis and urine culture). 151 samples showed no growth on culture plates for taking antibiotics at the time of collection of samples. The positive samples for pathogenic microorganisms were 197. Out of those positive cases gram negative bacteria were found responsible for 81.92% of UTIs in comparison to gram positive bacteria which were 18.08%. Escherichia coli were the most predominant uro-pathogen with 34% followed by Klebsiella spp. 18.78% and Staphylococcus spp. 12.67%. The prevalence of Candida spp. 20.30% was also very high in males and females. Urine culture is an important diagnostic tool to confirm UTI. Rules must be put on the consumption of antibiotics to limit their abuse and misuse. Physicians are advised to use antibiotics like sulzone, nitrofuration, tazocin and imipenum for gram negative bacteria and tetracycline against gram positive bacteria, these antibiotics showed a low resistance rate in that study over commonly used antibiotics.
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    ABSTRACT: This study was conducted to determine the predictive value of clinical, laboratory, and imaging variables for the diagnosis of vesicoureteral reflux in children with their first febrile urinary tract infection.
    Korean journal of urology 08/2014; 55(8):536-41. DOI:10.4111/kju.2014.55.8.536


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