Effect of Endocrine Disruptor Pesticides: A Review

Laboratoire de Biochimie, Unité de Recherche 02/UR/09-01, Institut Supérieur de Biotechnologie, de Monastir, BP 74, 5019 Monastir, Tunisia.
International Journal of Environmental Research and Public Health (Impact Factor: 2.06). 06/2011; 8(6):2265-303. DOI: 10.3390/ijerph8062265
Source: PubMed


Endocrine disrupting chemicals (EDC) are compounds that alter the normal functioning of the endocrine system of both wildlife and humans. A huge number of chemicals have been identified as endocrine disruptors, among them several pesticides. Pesticides are used to kill unwanted organisms in crops, public areas, homes and gardens, and parasites in medicine. Human are exposed to pesticides due to their occupations or through dietary and environmental exposure (water, soil, air). For several years, there have been enquiries about the impact of environmental factors on the occurrence of human pathologies. This paper reviews the current knowledge of the potential impacts of endocrine disruptor pesticides on human health.

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Available from: Benoit Roig, Nov 16, 2015
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    • "These compounds bioaccumulate and biomagnify within top-level predators and have been detected in the tissues of marine mammals world-wide (Braune et al., 2005; O'Shea, 1999; Law, 2014). The widespread use of these compounds has been associated with deleterious effects on the health and reproduction of wildlife (Bernanke and Köhler, 2009; Fisk et al., 2005; Mnif et al., 2011). In pinnipeds, reduced pup production , premature parturition, and altered immune function have been associated with exposure to OCs (DeLong et al., 1973; Gilmartin et al., 1976; Helle et al., 1976a, 1976b; Reijnders, 1986; Beckmen et al., 2003; De Swart et al., 1994, 1995a, 1995b, 1996; Ross et al., 1995, 1996). "
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    ABSTRACT: The relationships of selected organochlorine (OC) contaminants between blubber, blood, feces, and milk of young, free-ranging Steller sea lions (Eumetopias jubatus) were examined. Both between and within each tissue there was considerable individual variation. In spite of the variation, similar patterns were observed across the tissues for most of the selected PCB congeners. In all four tissues, the major PCB congeners were PCB101, PCB118, PCB138, and PCB153. The most prominent congener, both as a weight (ng/g lipid) and as a percentage of summed PCBs (∑PCBs), was PCB 153. Comparisons between paired tissues showed that ∑DDTs in blubber samples were related to concentrations in blood, feces, and milk. The ∑PCBs in blubber were related to concentrations in milk and fecal samples, though the relationship with feces was weak. Our findings show milk samples, in particular, are useful for assessing OCs in young sea lions. Blubber concentrations of PCB101, PCB118, and PCB138 were an order of magnitude higher than those in milk, supporting the biomagnification of these PCB congeners in SSL tissues. The findings indicate alternative tissues may be used as indicators of relative contaminant exposure in lieu of surgical blubber biopsy.
    Science of The Total Environment 11/2015; 542(Pt A):441-452. DOI:10.1016/j.scitotenv.2015.10.119 · 4.10 Impact Factor
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    • "The capacity of azole fungicides to cause endocrine disruption has been demonstrated (Brande-Lavridsen et al., 2008; Goetz et al., 2007; Jacobsen et al., 2012; Kjaerstad et al., 2010; Mnif et al., 2011; Taxvig et al., 2007; Yu et al., 2013). These fungicides inhibit fungal growth by specifically inhibiting the cytochrome P450- mediated C 14 -de-methylation step in the biosynthesis of ergosterol, a biomolecule unique in fungi. "
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    • "A large number of pesticides have been identified as endocrine-disrupting chemicals (EDC) (Mnif et al., 2011), defined as exogenous agents that interfere with synthesis, secretion , transport, binding, action, or elimination of natural hormones in the body that are responsible for maintenance of homeostasis, reproduction, development, and or behavior (U.S. Environmental Protection Agency [EPA], 1997). Frequently reported adverse effects in experimental animals chronically exposed to EDC are decreased fertility in both genders, increased rate of miscarriages, and altered sex ratio (Shojaei-Saadi and Abdollahi, 2012; Yoon et al., 2014). "
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