Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: A 6-month randomized placebo-controlled trial

Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, Lubbock, TX 79430-9097, USA.
Osteoporosis International (Impact Factor: 4.17). 07/2011; 23(5):1541-52. DOI: 10.1007/s00198-011-1731-x
Source: PubMed


Postmenopausal women with osteopenia received green tea polyphenols (GTP) supplement and/or Tai Chi exercise for 6 months. Bone turnover biomarkers, calcium metabolism, and muscle strength were measured. This study showed that GTP supplementation and Tai Chi exercise increased bone formation biomarkers and improved bone turnover rate. Tai Chi exercise increased serum parathyroid hormone. GTP supplementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.
This study evaluated the effect of GTP supplementation and Tai Chi (TC) exercise on serum markers of bone turnover (bone-specific alkaline phosphatase, BAP, and tartrate-resistant acid phosphatase, TRAP), calcium metabolism, and muscle strength in postmenopausal osteopenic women.
One hundred and seventy-one postmenopausal osteopenic women were randomly assigned to four groups: (1) placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) placebo + TC (placebo plus TC training at 60 min/session, three sessions/week), and (4) GTP + TC (GTP plus TC training). Overnight fasting blood and urine samples were collected at baseline, 1, 3, and 6 months for biomarker analyses. Muscle strength was evaluated at baseline, 3, and 6 months. One hundred and fifty subjects completed the 6-month study.
Significant increases in BAP level due to GTP intake (at 1 month) and TC (at 3 months) were observed. Significant increases in the change of BAP/TRAP ratio due to GTP (at 3 months) and TC (at 6 months) were also observed. Significant main effect of TC on the elevation in serum parathyroid hormone level was observed at 1 and 3 months. At 6 months, muscle strength significantly improved due to GTP, TC, and GTP + TC interventions. Neither GTP nor TC affected serum TRAP, serum and urinary calcium, and inorganic phosphate.
In summary, GTP supplementation and TC exercise increased BAP and improved BAP/TRAP ratio. TC exercise increased serum parathyroid hormone. GTP supplementation, TC exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.

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Available from: Bahram H Arjmandi, Oct 02, 2015
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    • "In this study, we did not find any change in Ca levels of serum during GTE treatment. Other studies have shown that supplementation with GT polyphenols results in an increase in bone-mineral density and a decrease in urinary calcium levels [38, 39]. In this study, we did not evaluate the concentration of this mineral in other tissues, such as bones. "
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    • "Patterns of postmenopausal BMD loss vary with respect to race and ethnicity, and nearly all prior RCTs evaluating TC for BMD have been conducted in Asia. Our results are in concordance with a recently completed U.S. study of osteopenic women that reported 6 months of Tai Chi improved multiple markers of bone health including higher levels of bone-specific alkaline phosphotase (BAP), higher ratios of BAP to tartrate-resistant acid phosphotase, and elevated levels of serum parathyroid levels [42,43]. Third, in contrast to previous RCTs that targeted relatively sedentary populations, we included women who were relatively active since exercise is a standard recommendation for osteopenia. "
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