Article

Resonance light scattering as a powerful tool for sensitive detection of β-amyloid peptide by gold nanoparticle probes.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Chemical Communications (impact factor: 6.17). 09/2011; 47(33):9339-41. DOI:10.1039/c1cc12939b pp.9339-41
Source: PubMed

ABSTRACT A novel biosensing strategy has been developed for sensitive detection of β-amyloid 1-42 (Aβ(1-42)) down to the ng mL(-1) level in both aqueous solution and diluted human plasma, which is based on measuring changes in resonance light scattering of streptavidin functionalized gold nanoparticles as a function of the concentration of Aβ(1-42) with a conventional spectrofluorometer.

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Keywords

aqueous solution
 
conventional spectrofluorometer
 
human plasma
 
resonance light scattering
 
streptavidin functionalized gold nanoparticles
 

Chengke Wang