Optimizing Chemotherapy-Free Survival for the ER/HER2-Positive Metastatic Breast Cancer Patient

University of Miami's Sylvester Comprehensive Cancer Center, Miami, Florida, USA.
Clinical Cancer Research (Impact Factor: 8.72). 08/2011; 17(17):5559-61. DOI: 10.1158/1078-0432.CCR-10-2051
Source: PubMed


The recent incremental advances made in the treatment of metastatic breast cancer have elicited potential for survival extension in this treatable, yet incurable, population of breast cancer patients. Clinicians have focused on targeted therapies, which aim at signaling receptors such as the human epidermal receptor superfamily, the estrogen receptor, VEGF, the insulin-like growth factor receptor, the hepatocyte growth factor receptor (cMET), phosphoinositide 3-kinase, mTOR, and many others. Clin Cancer Res; 17(17); 5559-61. (C)2011 AACR.

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