Article

Clinical significance of pretreatment serum C-reactive protein level in soft tissue sarcoma.

Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu City, Japan.
Cancer (impact factor: 4.77). 07/2011; 118(4):1055-61. DOI:10.1002/cncr.26353 pp.1055-61
Source: PubMed

ABSTRACT The aim of this study was to determine whether circulating C-reactive protein (CRP) levels before treatment predict the overall survival and disease-free survival in soft tissue sarcoma patients.
A total of 102 primary soft tissue sarcoma patients from 2003 to 2009 were retrospectively reviewed. The CRP levels were obtained before treatment for all patients. The patients who presented with metastases at diagnosis were excluded from this study.
Elevated CRP levels were seen in 18 patients. The tumor histological grade and American Joint Committee on Cancer stage in the patients with elevated CRP levels were significantly higher than those in patients with normal CRP levels. Patients with elevated CRP levels before initial treatment had a poorer overall survival than patients with normal CRP levels (P = .01). The overall survival estimates at 3 and 5 years were 75.3% and 53.8%, respectively, versus 90.3% and 81.3%, respectively. Patients with elevated CRP levels before initial treatment had poorer event-free survival after initial treatment than patients with normal CRP levels (P < .001). The event-free survival estimates at 2 and 5 years were 53.2% and 33.2%, respectively, versus 83.2% and 81.3%, respectively. A multivariate analysis also showed the preoperative CRP level to be an independent predictor of events.
The pretreatment serum CRP level may be a marker of aggressive tumor characteristics. Pretreatment elevated CRP levels were found to be a poor prognostic factor for overall survival in a univariate analysis, and for disease-free survival in a multivariate analysis, for soft tissue sarcoma patients.

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  • Article: Optimization of the systemic inflammation-based Glasgow Prognostic Score: A Glasgow Inflammation Outcome Study.
    Michael J Proctor, Paul G Horgan, Dinesh Talwar, Colin D Fletcher, David S Morrison, Donald C McMillan
    [show abstract] [hide abstract]
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Keywords

102 primary soft tissue sarcoma patients
 
18 patients
 
aggressive tumor characteristics
 
American Joint Committee
 
Cancer stage
 
CRP levels
 
disease-free survival
 
Elevated CRP levels
 
event-free survival estimates
 
independent predictor
 
initial treatment
 
normal CRP levels
 
Patients
 
poor prognostic factor
 
preoperative CRP level
 
Pretreatment
 
pretreatment serum CRP level
 
soft tissue sarcoma patients
 
survival estimates
 
tumor histological grade