How Would Composite Traditional Chinese Medicine Protect the Brain – An Example of the Composite Formula “Pien Tze Huang”

Brain Research Centre, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Current Medicinal Chemistry (Impact Factor: 3.85). 08/2011; 18(23):3590-4. DOI: 10.2174/092986711796642535
Source: PubMed


Chinese medicine has a long history of several thousand years. The main form of Traditional Chinese Medicine (TCM) is composite, i.e. a mixture of up to 10 medicinal products. Thus a composite prescription of 4-5 kinds of Chinese medicinal products may contain several hundred kinds of chemical composition. The active ingredients and clinical efficacy of which are difficult to characterize. We aim to review the Chinese literature of TCMs with neuroprotective effects. We illustrate with our study on Pien Tze Huang (PZH) the use of in vivo tests in the study of composite TCM. Our results show evidence that PZH might have neuropreventive effects in rats.

Download full-text


Available from: Lanhai Lü, Feb 02, 2014
  • Source
    • "This would be the evaluation of the function upon recovery or establishment of de novo collateral functioning utilizing upon recovery by physiological or imaging studies (functional MRI), in addition to merely employing behavior tests. An example of this was depicted by studies in our laboratory [38, 77–79]. It is also imperative to see how long the recovered function would last upon cessation of treatments, or from another angle, how long would the period of treatment had to be employed. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Among hundreds of formulae of Chinese herbal prescriptions and recently extracted active components from the herbs, some of which had demonstrated their functions on nervous system. For the last decade or more, Gingko biloba and Polygala tenuifolia were widely studied for their beneficial effects against damage to the brain. Two compounds extracted from Apium graveolens and Rhizoma coptidis, butylphthalide and berberine, respectively, received much attention recently as potential neuroprotective agents. In this review, the two traditionally used herbs and the two relatively new compounds will be discussed with regard to their potential advantages in alleviating brain and other relevant ailments.
    Evidence-based Complementary and Alternative Medicine 05/2014; 2014(1):682717. DOI:10.1155/2014/682717 · 1.88 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: So far, the components responsible for the neuroprotective effects of Calculus Bovis are unclear. Cholesterol, one of the major components in Calculus Bovis, is easily oxidized into oxysterols which possess direct or indirect neuroprotective effects proved by our and others’ previous studies. Therefore, a liquid chromatography with mass spectrometry method coupled with ultrasonic extraction and solid-phase extraction was developed for the determination of neuroprotective oxysterols in Calculus Bovis, human gallstones and traditional Chinese medicine preparations. Chromatographic separation was achieved on a C18 column with isocratic elution at a flow rate of 1 mL/min. The established method showed good linearity (R2 > 0.998), sensitivity with low limits of detection (0.06–0.39 μg/g), acceptable precisions (relative standard deviations ≤ 7.4%), stability (relative standard deviations ≤ 5.9%) and satisfactory accuracy (92.4–102.9%) for all analytes identified by different retention times, which could be applied for the determination of oxysterols. Five kinds of oxysterols proved to function as neuroprotectants were detected at different concentrations. Among them, 7β-hydroxycholesterol and cholestane-3β,5α,6β-triol were rather abundant in the samples. It could be concluded that the potential neuroprotective components in Calculus Bovis may be these oxysterols.This article is protected by copyright. All rights reserved
    Journal of Separation Science 12/2014; 38(5). DOI:10.1002/jssc.201400850 · 2.74 Impact Factor