A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

Department of Dermatology, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.
Annals of Dermatology (Impact Factor: 1.39). 05/2011; 23(2):185-92. DOI: 10.5021/ad.2011.23.2.185
Source: PubMed


Many variants of dermatofibromas have been described, and being aware of the variants of dermatofibromas is important to avoid misdiagnosis.
We wanted to evaluate the clinical and pathologic characteristics of 122 cases of dermatofibromas.
We retrospectively reviewed the medical records and 122 biopsy specimens of 92 patients who were diagnosed with dermatofibroma in the Department of Dermatology at Eulji Hospital of Eulji University between January 2000 and March 2010.
Nearly 80% of the cases occurred between the ages of 20 and 49 years, with an overall predominance of females. Over 70% of the lesions were found on the extremities. The most common histologic variant was a fibrocollagenous dermatofibroma (40.1%). Other variants included histiocytic (13.1%), cellular (11.5%), aneurysmal (7.4%), angiomatous (6.5%), sclerotic (6.5%), monster (4.9%), palisading (1.6%) and keloidal dermatofibromas (0.8%). There were 9 dermatofibromas (7.3%) that were the mixed type with two co-dominant histologic features.
The results of this study are consistent with previous reports on the clinical features of dermatofibromas. However, we observed several characteristic subtypes of dermatofibroma and we compared the frequency of the histologic subtypes.

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    • "Dermatofibroma, also known as fibrous histiocytoma, is one of the most common cutaneous soft-tissue lesions, accounting for approximately 3% of skin lesion specimens received by dermatopathology laboratories.1 If the classical clinical and pathologic features are present the diagnosis is usually straightforward. "
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    ABSTRACT: Several variants of dermatofibroma have been described. They are essentially distinguished by their clinical and histopathological features. To review the mainfeaturesof these variants, a retrospective study of skin biopsies and tissue excisions of dermatofibromasperformed in the dermatology and venereology service at the Hospital Garcia de Orta between May 2007 and April 2012 was carried out. During that period, 192 dermatofibromas were diagnosed in 181 patients, the lesions being more common in women. Median age of the study population was 48 years. The most common lesion site was the limbs (74% of patients). The histopathological types found were common fibrous histiocytoma (80%) and the aneurysmal (5.7%),hemosiderotic (5.7%), epithelioid (2.6%), cellular (2.1%), lipidized (2.1%), atrophic (1.0) and clear cell (0.5%) variants. Based on these findings, this review focuses on the clinical and histological features of the various variants of dermatofibroma in terms of their clinical presentation, distinct histopathological features, differential diagnosis and prognosis.
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    ABSTRACT: Dermatofibroma (DF), a common benign skin tumour, sometimes requires treatment either because of cosmetic concern or for associated symptoms. However, no effective treatment with optimal cosmetic outcomes has been reported. An effective and safe therapeutic option could be treatment with pulsed dye laser (PDL). Twenty-two DFs in 15 patients were treated with PDL at 595-nm wavelength, using a spot size of 7 mm, a pulse duration of 2 ms and a fluence of 11 J/cm(2) with 2 or 3 stacked pulses. Clinical and dermoscopic photographs were taken before and after therapy. Global clinical improvement was higher than 50% in 12 lesions. Patient satisfaction assessment showed 73% of patients as satisfied or very satisfied. All lesions showed changes from the previous dermoscopic pattern. We consider that PDL could be a safe, palliative treatment as it is well accepted by patients and has a better cosmetic outcome than surgical excision.
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    ABSTRACT: Fibrous histiocytomas are divided into two subgroups: malignant and benign fibrous histiocytomas (BFHs). BFH is one of the most common tumors of the superficial and deep soft tissues; it is commonly found on the skin and presents as a slow-growing solitary nodule made up of a mixture of fibroblastic and histiocytic cells. In this study, we present the case of a 45-year-old female who was histopathologically diagnosed with dermatofibrosarcoma protuberans (DFSP) and received radiotherapy, but whose diagnosis was changed to BFH based on subsequent immunohistochemical analyses. BFH is a mesenchymal soft-tissue tumor with fibroblastic and histiocytic differentiation. Differential diagnosis for BFH found in deeper tissues includes other aggressive fibrohistiocytic lesions, such as DFSP and malignant fibrous histiocytoma. Differentiating among these tumors is crucial in selecting the correct surgical strategy and patient management in the postoperative period. In most cases, the pleomorphism and atypical mitotic activity seen histopathologically are sufficient for the differentiation between benign and malignant tumors. Immunohistochemical staining methods should be used in cases that are difficult to diagnose. The treatment of choice for BFH is wide resection of the tumor, which results in an excellent prognosis and low recurrence rate. In agreement with cases reported in the literature, our case confirms that wide excision is adequate to prevent the recurrence of the tumor. Although benign fibrous histiocytomas is rare, it must be considered in the differential diagnosis of tumors arising from the soft-tissue.
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