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    ABSTRACT: The oxidation was performed of 2-(6,6-dimethylbicyclo[3.1.1]hept-2-ylmethylsulfanyl)ethanol II synthesized by adding 2-mercaptoethanol to (−)-β-pinene in the presence of a Lewis acid. The sulfoxide obtained is present in two polymorphic structures with different physical properties, spectral characteristics, and fungicidal activity.
    Russian Journal of General Chemistry 03/2012; 82(3). DOI:10.1134/S1070363212030139 · 0.48 Impact Factor
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    ABSTRACT: Although the practice of oncology can be extremely rewarding, it is also one of the most demanding and stressful areas of medicine. Oncologists are faced with life and death decisions on a daily basis, administer incredibly toxic therapies with narrow therapeutic windows, must keep up with the rapid pace of scientific and treatment advances, and continually walk a fine line between providing palliation and administering treatments that lead to excess toxicity. Personal distress precipitated by such work-related stress may manifest in a variety of ways including depression, anxiety, fatigue, and low mental quality of life. Burnout also seems to be one of the most common manifestations of distress among physicians, with studies suggesting a prevalence of 35% among medical oncologists, 38% among radiation oncologists, and 28% to 36% among surgical oncologists. Substantial evidence suggests that burnout can impact quality of care in a variety of ways and has potentially profound personal implications for physicians including suicidal ideation. In this review, we examine the causes, consequences, and personal ramifications of oncologist burnout and explore the steps oncologists can take to promote personal well-being and professional satisfaction.
    Journal of Clinical Oncology 03/2012; 30(11):1235-41. DOI:10.1200/JCO.2011.39.7380 · 18.43 Impact Factor
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    ABSTRACT: OBJECTIVE To evaluate factors associated with work-home conflicts (W-HCs) of US surgeons and their potential personal and professional consequences. DESIGN Cross-sectional study. PARTICIPANTS Members of the American College of Surgeons. MAIN OUTCOME MEASURES Burnout, depression, quality of life, alcohol use, career satisfaction, and career decisions (ie, reduce work hours or leave current practice). RESULTS Of 7197 participating surgeons, 3754 (52.5%) had experienced a W-HC in the previous 3 weeks. On multivariate analysis, hours worked per week, having children, sex, and work location (Veterans Administration or academic center) were independently associated with an increased risk for W-HC (all P < .01), while some factors (increased age and subspecialty field) reduced the risk. Surgeons with a recent W-HC were more likely to have symptoms of burnout (36.9% vs 17.1%; P < .001), depression (50.9% vs 28.1%; P < .001), alcohol abuse/dependency (17.2% vs 14.4%; P = .003), and were less likely to recommend surgery as a career option to their children (46.0% vs 54.4%; P < .001). Work-home conflicts were also independently associated with surgeons reporting a moderate or higher likelihood of planning to reduce clinical work hours (odds ratio, 1.769) and leave their current practice in the next 24 months for a reason other than retirement (odds ratio, 1.706) after controlling for other personal and professional factors. CONCLUSIONS Integrating personal and professional lives is a substantial challenge for US surgeons. Conflict in this balance appears to be a major factor in their decision to reduce work hours and/or move to a new practice, with potential substantive manpower implications for the surgical workforce.
    Archives of surgery (Chicago, Ill.: 1960) 10/2012; 147(10):933-9. DOI:10.1001/archsurg.2012.835 · 4.93 Impact Factor
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