Article

Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure.

Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.
Acta biomaterialia (Impact Factor: 5.68). 06/2011; 7(10):3563-72. DOI: 10.1016/j.actbio.2011.06.028
Source: PubMed

ABSTRACT Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for bone defects resulting from malignant bone tumors. The development of bioactive materials with magnetic and drug delivery properties may potentially meet this target. The aim of this study was to develop a multifunctional mesoporous bioactive glass (MBG) scaffold system for both hyperthermic and local drug delivery applications. To this end iron (Fe)-containing MBG (Fe-MBG) scaffolds with a hierarchical large pores structure (300-500 μm) and fingerprint-like mesopores (4.5 nm) have been prepared. The effects of Fe on the mesopore structure and physiochemical, magnetic, drug delivery and biological properties of MBG scaffolds have been systematically investigated. The results show that the morphology of the mesopores varied from straight channels to curved fingerprint-like channels after incorporation of Fe into MBG scaffolds. The magnetism of MBG scaffolds can be tailored by controlling the Fe content. Furthermore, the incorporation of Fe into mesoporous MBG glass scaffolds enhanced the mitochondrial activity and the expression of bone-related genes (ALP and OCN) in human bone marrow mesenchymal stem cells (BMSC) attached to the scaffolds. The Fe-MBG scaffolds obtained also possessed high specific surface areas and demonstrated sustained drug delivery. Thus Fe-MBG scaffolds are magnetic, degradable and bioactive. The multifunctionality of Fe-MBG scaffolds suggests that there is great potential for their use in the treatment and regeneration of large-bone defects caused by malignant bone tumors through a combination of hyperthermia, local drug delivery and osteoconductivity.

0 Bookmarks
 · 
139 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study is to prepare Ca, P and Si-containing ternary oxide nagelschmidtite (NAGEL, Ca7Si2P2O16) bioceramics and explore their in vitro bioactivity for potential bone tissue regeneration. We prepared dense NAGEL ceramics through high-temperature sintering of NAGEL ceramic powders. The apatite-mineralization ability, dissolution rate, and human osteoblast response (including cytotoxicity analysis, attachment, morphology, proliferation, and bone-related gene expression) to NAGEL ceramics have been systematically studied by comparing with conventional β-tricalcium phosphate (β-TCP) ceramics. The results showed that NAGEL ceramics possessed more obvious apatite mineralization and dissolution (degradation) and stimulated bone-related gene expression (OCN and OPN) of osteoblasts than β-TCP ceramics. NAGEL ceramics also showed no significant cytotoxicity. NAGEL ceramics supported osteoblast attachment, proliferation, and osteogenic gene expression, with a comparable cell proliferation activity with β-TCP ceramics. These results indicate that novel NAGEL bioceramics with the specific composition of Ca7Si2P2O16, are a promising biomaterial for bone tissue regeneration application.
    Journal of the American Ceramic Society 03/2013; 96(3). · 2.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report a facile method for fabricating monodispersed mesoporous bioactive glass sub-micron spheres (MBGS) using dodecylamine (DDA) as a catalyst and template agent in a sol-gel process by self-assembly between a neutral organic surfactant and neutral inorganic precursor (S0I0). Moreover, we investigate the effect of sub-micron particle size on the physicochemical properties, apatite-forming ability, and biocompatibility of MBGS. Results showed that all samples exhibited regular spherical morphology and favorable mono-dispersibility. The average particle diameters of MBGS (200-800 nm) were controlled by adjusting the concentration of DDA. All samples induced the formation of rod-like apatite precipitates, which closely resembled the natural nanoscale apatite crystal, showing their high apatite-forming ability. Furthermore, MBGS surfaces also supported the attachment and promoted proliferation of alkaline phosphatase (ALP) activity of MG-63 cells, showing the good biocompatibility of MBGS. MBGS-1 had the smallest particle size and it was found that it could significantly enhance MG-63 proliferation and differentiation because of the smaller particle size and higher specific surface area. It is hoped that this study may motivate the development and applications of submicron biomaterials for bone repair applications.
    RSC Advances 01/2014; 4(43):22678. · 3.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Research on mesoporous materials for biomedical and biological applications has experienced an outstanding increase during recent years. This review with ca. 420 references provides an overview of mesoporous structures covering synthesis and bioapplications. Various methods of mesoporous material preparation and modification are discussed as controlled synthesis of these molecular sieves has great impact on their properties and applications. In the area of bioapplications, mesoporous materials offer the potential for drug delivery, bioimaging, regenerative medicine, optical and electrochemical biosensing, enzyme immobilization, biomolecule sorption and separation and many others. We also discuss the cytotoxicity aspects of mesoporous structures being of crucial importance for successful application of these novel tools in the biomedical field. Future prospects of mesoporous materials have been also briefly discussed. We believe that the present review will serve as a comprehensive guide for scientists in the area of biosciences giving the background in regard to mesoporous materials. Copyright © 2014 Elsevier B.V. All rights reserved.
    Materials Science and Engineering C 04/2015; 49. · 2.74 Impact Factor

Full-text (2 Sources)

Download
25 Downloads
Available from
May 29, 2014