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Phentermine plus topiramate in the treatment of obesity

The Lancet (Impact Factor: 45.22). 07/2011; 378(9786):125-6; author reply 126-7. DOI: 10.1016/S0140-6736(11)61080-5
Source: PubMed
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    • "This distinguishes ER-b–selective ligands from most of the new chemical entities under development [e.g., Lorcarserin (Arena Pharmaceuticals), Qnexa (Vivus Inc.), and Contrave (Orexigen Ltd.)], which reduce body weight by suppressing appetite through targets in the central nervous system. Unfortunately, many anti-obesity drugs belonging to similar classes were eventually withdrawn from the market due to cardiovascular side effects (Connolly et al., 1997; Malgarini and Pimpinella, 2011). Since long-term activation of ER-a could have unwarranted side effects (e.g., thromboembolism and breast and uterine cancers), we examined the effects of ER-b–selective agonists on the hypothalamus– pituitary–gonadal axis in males fed a high-fat diet and on uterine weight in females with ovariectomy-induced weight gain to ensure the absence of cross-reactivity with ER-a. "
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