MiR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis

Department of Pathology, New York University Medical Center, NY 10016, USA.
Cancer cell (Impact Factor: 23.52). 07/2011; 20(1):104-18. DOI: 10.1016/j.ccr.2011.05.027
Source: PubMed

ABSTRACT To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment. These data support a key role of miR-30b/30d and GalNAc transferases in metastasis, by simultaneously promoting cellular invasion and immunosuppression.

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Available from: Miguel F Segura, Sep 26, 2015
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    Cancer Medicine 06/2014; 3(3). DOI:10.1002/cam4.233 · 2.50 Impact Factor
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    • "In melanoma, a highly metastatic tumor, miR-199a-3p, miR-199a-5p, and miR-1908 promote metastatic invasion, angiogenesis, and colonization by targeting the apolipoprotein E and the heat shock factor DNAJA4.88 Expression of these three miRNAs directly correlates with melanoma metastatic outcome. Overexpression of miR-30b/miR-30d also correlates with stage, metastatic potential, and reduced overall survival in melanoma patients.89 Accordingly, ectopic expression of miR-30b/miR-30d in melanoma cells increased their metastatic behavior by a dual mechanism – promoting invasion and immunosuppression by directly targeting the GalNAc transferase GALNT7.89 "
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