Therapy-, gender- and race-specific microRNA markers, target genes and networks related to glioblastoma recurrence and survival

Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA.
Cancer genomics & proteomics 07/2011; 8(4):173-83.
Source: PubMed


To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses.
microRNAs associated with glioblastoma survival within and across race, gender, recurrence, and therapy cohorts were identified using 253 individuals, 534 microRNAs, Cox survival model, cross-validation, discriminant analyses, and cross-study comparison.
All 45 microRNAs revealed as being associated with survival were confirmed in independent cancer studies and 25 in glioblastoma studies. Thirty-nine and six microRNAs (including hsa-miR-222) were associated with one and multiple glioblastoma survival indicators, respectively. Nineteen and 26 microRNAs exhibited cohort-dependent (including hsa-miR-10b with therapy and hsa-miR-486 with race) and independent associations with glioblastoma, respectively.
Sensory perception and G protein-coupled receptor processes were enriched among microRNA gene targets also associated with survival and network visualization highlighted their relations. These findings can help to improve prognostic tools and personalized treatments.

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    • "In another study including 38 GBM samples, miR-21, miR-181c, miR-195, and miR-196b were associated with survival of GBM patients [32]. Using TCGA dataset with 253 individuals, 23 and 19 miRNAs were defined to be associated with OS and PFS, respectively [7]. Also, in another publication with 222 GBM samples, a risk score, formulated on the basis of expression signatures of 10 miRNAs, was associated with GBM patient survival, which was suggested to predict GBM patient survival [33]. "
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