Article

Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease.

Department of Basic Nursing, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Microbes and Infection (Impact Factor: 2.73). 06/2011; 13(12-13):1002-5. DOI: 10.1016/j.micinf.2011.06.002
Source: PubMed

ABSTRACT Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.

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    Microbial Pathogenesis: Infection and Immunity, Edited by Uday Kishore, Annapurna Nayak, 01/2014: pages 167-202; Springer-Landes Bioscience., ISBN: 978-1-4614-9529-1

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