Breastfeeding: More Than Just Good Nutrition

Pediatric Immunology and Infectious Diseases, University of Florida- Health Science Center, Gainesville, FL, USA.
Pediatrics in Review (Impact Factor: 0.82). 07/2011; 32(7):267-80. DOI: 10.1542/pir.32-7-267
Source: PubMed

ABSTRACT • Ample evidence documents the clear benefits of breastfeeding for both the mother and the infant. • Among the very few contraindications to breastfeeding are galactosemia, medications or drugs of concern, and HIV and HTLV infection. • Pediatricians should recognize that human milk is superior to formula in optimizing each infant's potential for early growth and development. • Pediatricians should recommend exclusive/full breastfeeding as superior to formula feeding through the first 6 postnatal months and the subsequent timely introduction of adequate, safe, and appropriate complementary foods in combination with continued breastfeeding as optimal nutrition in the first postnatal year. • Pediatricians should be knowledgeable about important issues concerning breastfeeding and the management of the breastfeeding mother-infant dyad in situations of infant prematurity or illness and maternal illness, infection, and medication exposure. • Families should be provided with appropriate information about breastfeeding and infant feeding before as well as throughout the pregnancy and infancy. • Mothers should receive ongoing support for breastfeeding in the hospital, in medical offices and facilities, and throughout communities, paralleling the BFHI. • Ongoing lifelong education about support for and management of the breastfeeding mother-infant dyad is essential for pediatricians in the 21st century. 2011

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    ABSTRACT: Objective: The aim of the present study was to investigate the metabolic profile of preterm human breast milk (HBM) by using a metabolomic approach. Methods: NMR spectroscopy and GC/MS were used to analyze the water-soluble and lipid fractions extracted from milk samples obtained from mothers giving birth at 26-36 weeks of gestation. For the sake of comparison, preterm formula milk was also studied. Results: The multivariate statistical analysis of the data evidenced biochemical variability both between preterm HBM and commercial milk and within the group of HBM samples. Conclusions: The preliminary results of this study suggest that metabolomics may provide a promising tool to study aspects related to the nutrition and health of preterm infant.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 10/2012; 25(Suppl 5):62-7. DOI:10.3109/14767058.2012.715436 · 1.37 Impact Factor
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    Archives of dermatology 12/2012; 149(3):1-7. DOI:10.1001/jamadermatol.2013.1560 · 4.79 Impact Factor
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    ABSTRACT: Background: Very low birth weight (VLBW) and premature infants are at risk for developing postnatal cytomegalovirus (CMV) disease, including CMV-related sepsis-like syndrome (CMV-SLS) for which estimates [corrected] in the United States are lacking. Methods: We performed a systematic review and meta-analysis to estimate the pooled proportions (and 95% confidence intervals) of VLBW and premature infants born to CMV-seropositive women with breast milk-acquired CMV infection and CMV-SLS. We combined these proportions with population-based rates of CMV seropositivity, breast milk feeding, VLBW, and prematurity to estimate annual rates of breast milk-acquired CMV infection and CMV-SLS in the United States. Results: In our meta-analysis, among 299 infants fed untreated breast milk, we estimated 19% (11%-32%) acquired CMV infection and 4% (2%-7%) developed CMV-SLS. Assuming these proportions, we estimated a rate of breast milk-acquired CMV infection among VLBW and premature infants in the United States of 6.5% (3.7%-10.9%) and 1.4% (0.7%-2.4%) of CMV-SLS, corresponding to 600 infants with CMV-SLS in 2008. Among 212 infants fed frozen breast milk, our meta-analysis proportions were 13% (7%-24%) for infection and 5% (2%-12%) for CMV-SLS, yielding slightly lower rates of breast milk-acquired CMV infection (4.4%; 2.4%-8.2%) but similar rates of CMV-SLS (1.7%; 0.7%-4.1%). Conclusions: Breast milk-acquired CMV infection presenting with CMV-SLS is relatively rare. Prospective studies to better define the burden of disease are needed to refine guidelines for feeding breast milk from CMV-seropositive mothers to VLBW and premature infants.
    PEDIATRICS 05/2013; 131(6). DOI:10.1542/peds.2013-0076 · 5.47 Impact Factor
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