Patient-reported outcomes in chronic gout: A report from OMERACT 10

Medicine Service, Birmingham Veterans Affairs (VA) Medical Center and Division of Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.
The Journal of Rheumatology (Impact Factor: 3.19). 07/2011; 38(7):1452-7. DOI: 10.3899/jrheum.110271
Source: PubMed


To summarize the endorsement of measures of patient-reported outcome (PRO) domains in chronic gout at the 2010 Outcome Measures in Rheumatology Meeting (OMERACT 10).
During the OMERACT 10 gout workshop, validation data were presented for key PRO domains including pain [pain by visual analog scale (VAS)], patient global (patient global VAS), activity limitation [Health Assessment Questionnaire-Disability Index (HAQ-DI)], and a disease-specific measure, the Gout Assessment Questionnaire version 2.0 (GAQ v2.0). Data were presented on all 3 aspects of the OMERACT filters of truth, discrimination, and feasibility. One PRO, health-related quality of life measurement with the Medical Outcomes Study Short-form 36 (SF-36), was previously endorsed at OMERACT 9.
One measure for each of the 3 PRO of pain, patient global, and activity limitation was endorsed by > 70% of the OMERACT delegates to have appropriate validation data. Specifically, pain measurement by VAS was endorsed by 85%, patient global assessment by VAS by 73%, and activity limitation by HAQ-DI by 71%. GAQ v2.0 received 30% vote and was not endorsed due to several concerns including low internal consistency and lack of familiarity with the measure. More validation studies are needed for this measure.
With the endorsement of one measure each for pain, patient global, SF-36, and activity limitation, all 4 PRO for chronic gout have been endorsed. Future validation studies are needed for the disease-specific measure, GAQ v2.0. Validation for PRO for acute gout will be the focus of the next validation exercise for the OMERACT gout group.

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Available from: Jasvinder A Singh, Sep 20, 2015
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    • "Today, effective treatments are available for gout but it has not yet been determined whether, in order to minimise long-term detrimental outcomes, its prevention and management should primarily target risk factors and comorbidities rather than disease mechanisms [9]. The relevance of assessing patient-oriented outcomes, such as functional ability and HRQoL, has been recently recognised by the Outcome Measures in Rheumatology Clinical Trial (OMERACT) [8,10,11]. "
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