Association between urinary arsenic and diabetes mellitus in the Korean general population according to KNHANES 2008.
ABSTRACT We present data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008 on the associations between urinary arsenic and diabetes mellitus in a representative sample of the adult Korean population.
This study was based on data obtained in KNHANES 2008, which was conducted for three years (2007-2009) using a rolling sampling design involving a complex, stratified, multistage, probability-cluster survey of a representative sample of the noninstitutionalized civilian population of South Korea.
Geometric means of total urinary arsenic concentration in females and total participants with diabetes mellitus were significantly higher than in participants without diabetes mellitus after adjustment for covariates, including age, seafood consumption, body mass index (BMI), hypertension, area of residence, regional area, education level, and smoking and drinking status. Multiple regression analysis after similar adjustment showed that total urinary arsenic concentration was associated with diabetes status in the females and total participants. In addition, after similar adjustment, the odds ratios (ORs) for diabetes mellitus in female participants and all participants were 1.502 (95% CI, 1.038-2.171) and 1.312 (95% CI, 1.040-1.655), respectively, for doubling of the level of urinary total arsenic concentration.
This study showed an association between total urinary arsenic concentration and the prevalence of diabetes mellitus in a representative sample of the adult population, especially women, with environmental arsenic exposure after adjustment for seafood intake and relevant diabetes risk factors.
Article: Exposure to low level of arsenic and lead in drinking water from Antofagasta city induces gender differences in glucose homeostasis in rats.[show abstract] [hide abstract]
ABSTRACT: Populations chronically exposed to arsenic in drinking water often have increased prevalence of diabetes mellitus. The purpose of this study was to compare the glucose homeostasis of male and female rats exposed to low levels of heavy metals in drinking water. Treated groups were Sprague-Dawley male and female rats exposed to drinking water from Antofagasta city, with total arsenic of 30 ppb and lead of 53 ppb for 3 months; control groups were exposed to purified water by reverse osmosis. The two treated groups in both males and females showed arsenic and lead in the hair of rats. The δ-aminolevulinic acid dehydratase was used as a sensitive biomarker of arsenic toxicity and lead. The activity of δ-aminolevulinic acid dehydratase was reduced only in treated male rats, compared to the control group. Treated males showed a significantly sustained increase in blood glucose and plasma insulin levels during oral glucose tolerance test compared to control group. The oral glucose tolerance test and the homeostasis model assessment of insulin resistance demonstrated that male rats were insulin resistant, and females remained sensitive to insulin after treatment. The total cholesterol and LDL cholesterol increased in treated male rats vs. the control, and triglyceride increased in treated female rats vs. the control. The activity of intestinal Na+/glucose cotransporter in male rats increased compared to female rats, suggesting a significant increase in intestinal glucose absorption. The findings indicate that exposure to low levels of arsenic and lead in drinking water could cause gender differences in insulin resistance.Biological trace element research 02/2012; 148(2):224-31. · 1.92 Impact Factor