Article

Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats.

Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Redox report: communications in free radical research (impact factor: 1.51). 01/2011; 16(2):56-61. DOI:10.1179/174329211X12989133691530
Source: PubMed

ABSTRACT The antioxidant effect of saponarin, which is the main flavone isolated from Gypsophila trichotoma Wend., and its protection against cocaine hepatotoxicity were investigated in male Wistar rats. The animals were treated with cocaine (40 mg/kg i.p.) alone and also after 3 consecutive days of pretreatment with saponarin (80 mg/kg p.o.). After 18 hours the rats were sacrificed by decapitation. The production of thiobarbituric acid reactive substances, reduced glutathione (GSH) and the activity of the following antioxidant enzymes: catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase were assessed in liver homogenate. Administered alone, cocaine induced significant hepatotoxicity manifested with GSH depletion and reduced antioxidant defences. Saponarin pretreatment, however, decreased cocaine toxicity both by increasing GSH levels and antioxidant enzyme activities. The results of this study proved the antioxidant activity of saponarin and its protective effect against cocaine-induced oxidative stress and hepatotoxicity.

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    Article: Interstitial lung damage due to cocaine abuse: pathogenesis, pharmacogenomics and therapy.
    Marjolein Drent, Petal Wijnen, Aalt Bast
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    Current Medicinal Chemistry 08/2012; · 4.86 Impact Factor
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Keywords

3 consecutive days
 
antioxidant activity
 
antioxidant defences
 
antioxidant effect
 
antioxidant enzyme activities
 
cocaine
 
cocaine hepatotoxicity
 
cocaine induced significant hepatotoxicity manifested
 
cocaine toxicity
 
cocaine-induced oxidative stress
 
following antioxidant enzymes
 
glutathione-S-transferase
 
GSH depletion
 
Gypsophila trichotoma Wend
 
liver homogenate
 
main flavone
 
pretreatment
 
protective effect
 
Saponarin pretreatment
 
thiobarbituric acid reactive substances