Article

Iron deficiency as a risk factor for simple febrile seizures-A case control study

Clinical Epidemiology Resource and Training Centre (CERTC), Medical College, Thiruvananthapuram, Kerala, India.
Indian pediatrics (Impact Factor: 1.01). 05/2011; 49(1):17-9. DOI: 10.1007/s13312-012-0008-6
Source: PubMed

ABSTRACT To study the role of iron deficiency as a risk factor for simple febrile seizures.
Case control study.
Pediatric department of a tertiary care teaching hospital.
154 cases and 154 controls were included in the study. Consecutive cases and concurrent controls were selected. Cases were children of age group 6 months to 3 years presenting with simple febrile seizures. Controls were children of same age group presenting with short febrile illness but without any seizures.
After informed consent, detailed history was taken and clinical examination done in both cases and controls and blood investigations were done to diagnose iron-deficiency in both cases and controls. Iron deficiency was diagnosed as per WHO criteria (hemoglobin value <11 g%, red cell distribution width of >15% and serum ferritin value <12 ng/mL). Other explanatory variables, which can be the potential confounders were also included in the study and considered for analysis.
Highly significant association was found between iron deficiency and simple febrile seizures in both univariate and multivariate analysis. Crude odds ratio was 5.34 (CI 3.27- 8.73, P<0.001) and adjusted odds ratio in the logistic regression analysis was 4.5 (CI 2.69- 7.53, P <0.001).
Iron deficiency is a significant risk factor for simple febrile seizures in children of age group 6 months to 3 years.

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    • "Iron serves many functions in the body both systemically, as well as on a tissue specific level. In the central nervous system (CNS), iron is an essential cofactor for many enzymes including those involved in energy metabolism, neurotransmitter synthesis , and the process of myelination (Conrad et al., 2000; Rao et al., 2003; Eden, 2005; Brotanek et al., 2007; Tran et al., 2008; Wu et al., 2008; Collard, 2009; Todorich et al., 2009; Tran et al., 2009; Kumari et al., 2012; Tran et al., 2012; Callahan et al., 2013; Polin et al., 2013; Radlowski and Johnson, 2013; Rao et al., 2013). Therefore, the impact of ID during vulnerable periods of neurodevelopment can be significant, and early gestational ID has been associated with abnormalities in neuronal development in both children and animals (Felt and Lozoff, 1996; Lozoff, 2000; Algarin et al., 2003; Walter, 2003; Lozoff and Georgieff, 2006; Rosato-Siri et al., 2010; Mihaila et al., 2011; Lee et al., 2012; Amin et al., 2013; Pisansky et al., 2013; Greminger et al., 2014; Jougleux et al., 2014) "
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    ABSTRACT: Febrile seizure is one of the most common neurological conditions of childhood. Several theories, such as iron deficiency anemia have been proposed as the pathogenesis of this condition. The aim of this study was to find the association between iron deficiency anemia and febrile seizures in children aged 6 months to 3 years admitted in Valie Asr hospital in Zanjan. Hemoglobin (Hb), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC) and SI/TIBC ratio were assessed in one hundred children with febrile seizures and compared to the values of one hundred healthy children presenting in a heath care center in the same period as the control group. A total of 6% of cases had iron deficiency anemia which was similar to the control group. In the case group SI/TIBC ratio below 12% was seen in 58% of children which was significantly higher than that of the control group (29%). The results of this study suggest that although anemia was not common among febrile seizure patients, iron deficiency was more frequent in these patients.
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