Long-Term Survival in a Rare Case of Malignant Esophageal Schwannoma Cured by Surgical Excision
ABSTRACT A full account is presented of a 44-year-old woman with an extremely rare case of a malignant esophageal schwannoma that had been misdiagnosed as a leiomyoma 3 years earlier. After surgical enucleation, the patient has survived for 6 years without any adjunctive treatment.
Article: Esophageal schwannoma: a case report[Show abstract] [Hide abstract]
ABSTRACT: Most tumorous lesions of the esophagus are esophageal cancers. Benign primary tumors of the esophagus are uncommon, and account for approximately 2% of all esophageal tumors. More than 80% of benign esophageal tumors are leiomyomas, with schwannomas being rare. A 55-year-old woman visited our internal medicine department with complaints of palpitations and discomfort during swallowing. A chest computed tomography scan showed a lobulated tumor (75 × 57 × 80 mm) in the upper to middle mediastinum, with homogenous inner opacity, compressing the esophagus. Upper gastrointestinal endoscopy revealed a smooth-surfaced elevated lesion covered with normal mucosa, and a schwannoma was diagnosed based on the biopsy result. The tumor was large. It was thus considered to be difficult to repair the esophagus by direct anastomosis after tumor resection. Therefore, subtotal esophagectomy and esophagogastrostomy in the right thorax were performed. Histopathological examination revealed spindle-shaped cells in a fasciculated and disarrayed architecture and nuclei in a palisading pattern. Immunohistochemical studies revealed S100 protein positivity and the absence of staining for α smooth muscle actin (αSMA), CD34 and CD117, thereby establishing the diagnosis of benign schwannoma. Her postoperative course was uneventful and there has been no evidence of recurrence to date.World Journal of Surgical Oncology 10/2013; 11:253-253. DOI:10.1186/1477-7819-11-253 · 1.20 Impact Factor
Article: Schwannoma of the cervical esophagus[Show abstract] [Hide abstract]
ABSTRACT: Esophageal schwannoma is a rare tumor first described in 1967 by Chaterlin and Fissore. These tumors are most commonly found incidentally or from diagnostic work up of dysphagia or dyspnea. This entity cannot be diagnosed on clinical or radiographic basis alone. Histology demonstrates palisading spindle cells, few if any mitotic figures, and a peripheral cuff of lymphoid cells. Immunohistochemically, tumor cells stain positive for S100, a characteristic marker of Schwann cells. Once diagnosed, surgical enucleation is the typical treatment method employed.Rare tumors 05/2014; 6(2):5361. DOI:10.4081/rt.2014.5361