Article

Effects of encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus rats.

College of Animal Science, Zhejiang University, No. 268 Kaixuan Road, Hangzhou 310029, China.
Evidence-based Complementary and Alternative Medicine (Impact Factor: 1.72). 01/2012; 2012:981896. DOI: 10.1155/2012/981896
Source: PubMed

ABSTRACT The present study investigates the encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus (T2DM) rats. The animal characteristics and biological assays of body weight, fasting blood glucose (FBG), fasting serum insulin (FINS), insulin act index (IAI), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured and euglycemic hyperinsulinemic glucose clamp technique were used to determine these effects. Our findings show that oral administration of encapsulated propolis can significantly inhibit the increasing of FBG and TG in T2DM rats and can improve IAI and M value in euglycemic hyperinsulinemic clamp experiment. There was no significant effects on body weight, TC, HDL-C, and LDL-C in T2DM rats treated with encapsulated propolis. In conclusion, the results indicate that encapsulated propolis can control blood glucose, modulate lipid metabolism, and improve the insulin sensitivity in T2DM rats.

5 Bookmarks
 · 
531 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored. The current study aimed to investigate the association of circulating CTRP1 and type 2 diabetes mellitus (T2DM) in a Chinese population. Serum CTRP1 and adiponectin levels of 96 T2DM patients and 85 healthy subjects were determined by ELISA, and their associations with adiposity, glucose and lipid profiles were studied. In a subgroup of this study, the 75-g oral glucose tolerance test (OGTT) was performed in 20 healthy and 20 T2DM subjects to evaluate the relationship among serum levels of CTRP1 and adiponectin, insulin secretion and insulin sensitivity. Serum CTRP1 levels were significantly increased in patients with T2DM, compared with healthy controls (p<0.001). Similar to adiponectin, serum levels of CTRP1 were significantly correlated to several parameters involved in glucose metabolism and insulin resistance, and independently associated with fasting glucose levels (p<0.05) after BMI and gender adjustments. Furthermore, CTRP1 levels were positively correlated to insulin secretion, while negatively to insulin sensitivity, as measured by OGTT. CTRP1 is a novel adipokine associated with T2DM in humans. The paradoxical increase of serum CTRP1 levels in T2DM subjects may be due to a compensatory response to the adverse glucose and lipid metabolism, which warrants further investigation.
    PLoS ONE 01/2014; 9(5):e94478. · 3.53 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To understand the mechanisms underlying the regulating dyslipidemia action of Chinese propolis and Brazilian green propolis, we investigated their effects on phosphatidylcholine-specific phospholipase C (PC-PLC) activity and annexin a7 (ANXA7) level which play crucial roles in the control of the progress of atherosclerosis. Furthermore, active oxygen species (ROS) levels, nuclear factor-KappaB p65 (NF- κ B p65), and mitochondrial membrane potential (MMP) were also investigated in oxidized-LDL- (ox-LDL-) stimulated human umbilical vein endothelial cells (HUVECs). Our data indicated that the treatment of both types of propolis 12.5 μ g/mL significantly increased cell viability and attenuated apoptosis rate, increased ANXA7 level, and decreased PC-PLC activity. Both types of propolis also inhibited ROS generation as well as the subsequent MMP collapse, and NF- κ B p65 activation induced by ox-LDL in HUVECs. Our results also indicated that Chinese propolis and Brazilian green propolis had similar biological activities and prevented ox-LDL induced cellular dysfunction in HUVECs.
    Evidence-based complementary and alternative medicine : eCAM. 01/2014; 2014:465383.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Obesity and type 2 diabetes mellitus (T2DM) are rapidly growing worldwide epidemics. It is accepted that interactions between obesity, insulin resistance, and β-cell dysfunction cause T2D, but the mechanisms regulating the interplay among these impairments remain unclear. Rodent models of high-fat diet (HFD)-induced obesity are used widely to study human diabesity. However, even with 9000+ rodent-based HFD publications on PubMed over the last decade, the mechanistic and therapeutic correlation to human diabesity has remained low. We investigated the reasons for this translational discrepancy by conducting a comprehensive review of HFD models. It appears that HFD models have limited translatable benefit due—at least in part—to divergent dietary compositions/protocols, species/strain variability, and inconsistent disease penetrance, severity, & duration. Combining HFD with other T2D induction modes exacerbates this species barrier—mechanistic insights from these studies are often confined to rodents, rather than being applicable to humans. Therefore, future research dedicated to acquiring transnationally relevant data would accelerate our understanding and development of therapeutics for human diabesity.
    Experimental Biology 2014; 04/2014

Full-text (2 Sources)

Download
6 Downloads
Available from