[The diffuse type of giant cell tumors of the tendon sheaths].
ABSTRACT The authors give a morphological and immunohistochemical description of diffuse giant cell tumors of the tendon sheath, which differ in the composition of neoplastic cells. Immunohistological detection of CD68, HAM56, CD45, and lysozyme is of crucial importance in the differential diagnosis with malignant soft tissue tumors. Attention is drawn to the high proliferative activity of tumor cells; the Ki-67 index is as high as 40% in occasional portions, which may give a misimpression of malignancy.
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ABSTRACT: The giant cell tumor of the tendon sheath is regarded as one of the most common neoplasms of the hand. This tumor usually manifests itself as a localized, solitary, painless and palpable subcutaneous nodule on the palmar aspect of a digit. A multifocal origin of the tumor has rarely been reported in the literature before. In this article we present a case of a giant cell tumor of the tendon sheath, in which two separate lesions developed simultaneously on the same tendon (flexor digitorum superficialis) of the little finger of the right hand together with a literature review about multifocal cases.02/2009; 20(2):119-23.