Prevalence of dyslipidemias in the Mexican National Health and Nutrition Survey 2006

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, DF, México.
Salud publica de Mexico (Impact Factor: 0.94). 01/2010; 52 Suppl 1(supl 1):S44-53. DOI: 10.1590/S0036-36342010000700008
Source: PubMed


To describe the prevalence of lipid abnormalities found in the Mexican National Health and Nutrition Survey 2006 (ENSANut 2006).
Information was obtained from 4 040 subjects aged 20 to 69 years, studied after a 9- to 12-hour fast.
Median lipid concentrations were: cholesterol 198.5 mg/dl, triglycerides 139.6 mg/dl, HDL-cholesterol 39.0 mg/dl, non-HDL-cholesterol 159.5 mg/dl and LDL-cholesterol 131.5 mg/dl. The most frequent abnormality was HDL-cholesterol below 40 mg/dl with a prevalence of 60.5% (95%CI 58.2-62.8%). Hypercholesterolemia (> 200 mg/dl) had a frequency of abnormality of 43.6% (95%CI 41.4-46.0%). Only 8.6% of the hypercholesterolemic subjects knew their diagnosis. Hypertriglyceridemia (>or= 150 mg/dl) was observed in 31.5% (IC 95% 29.3-33.9%) of the population.
The ENSANUT 2006 data confirm that the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high.

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    • "This syndrome is present in 5% to 45% of the general population [10]. Mexico has shown a high prevalence of dyslipidaemia in adults [11]. In 2004 Moran reported 9.5% of hypertriglyceridaemia and 20% of low HDL-C in a group of adolescents in Mexico [12]. "
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    ABSTRACT: Cerebral palsy people present movement difficulty and are liable to develop disorders associated with sedentary lifestyles such as dyslipidaemias and cardiovascular diseases. This study aimed to assess physical activity and the prevalence of lipid abnormalities in 29 children with cerebral palsy who were being treated in two care centers in the state of Guanajuato, Mexico. Physical activity was calculated using a survey. Blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides were determined. Forty-eight percent had at least one dyslipidaemia. The most frequent lipid abnormalities were hypertriglyceridaemia and low HDL-C. High prevalence of the atherogenic index was found. The physical activity of children was lower than recommended for their age. Sixty-two percent attended rehabilitation sessions, 10% attended sports classes, 14% rehabilitation plus sports and 14% did not engage in intentional physical activity. There is high frequency of lipid disorders in children with cerebral palsy. Greater participation in physical activity should be promoted in children to improve their metabolic status and quality of life, especially those suffering from cerebral palsy.
    Health 04/2014; 6(10):1030-1037. DOI:10.4236/health.2014.610129 · 0.51 Impact Factor
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    • "Prevalence of hypercholesterolemia in elderly from different countries of the world by sex [11] [12] [13] [14] [15] [16] [20] "
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    ABSTRACT: Hypercholesterolemia is a major cardiovascular risk factor that increases the incidence of atherosclerotic diseases in adults, although the association is less well established in the elderly. The role of statins is well characterized for the reduction of myocardial infarction incidence or death in individuals with a history or high risk of cardiovascular diseases, regardless of age. Therapeutic measures recommended to prevent cardiovascular diseases and to reduce cholesterol levels in the elderly, such as lifestyle changes and lipid-lowering drugs, particularly statins, are based on studies conducted in younger adults. This narrative review aims to summarize the main observational studies and randomized clinical trials that have studied the relationship between cholesterol and cardiovascular diseases and the potential benefits and drawbacks of statins use in elderly patients.
    Aging and Disease 06/2013; 4(3):154-69. · 3.07 Impact Factor
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    • "Additionally, GWAS often have association signals spanning many genes, which results in several potential gene candidates that cannot be narrowed down using GWAS alone. The Mexican population has a high risk of dyslipidemia, with 31.5% of the population suffering from hypertriglyceridemia (TGs>1.7 mmol/l) [4]. Additionally, no genome-wide transcriptome analysis for lipids to date has been performed in Mexicans. "
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    ABSTRACT: Background High serum triglyceride (TG) levels is an established risk factor for coronary heart disease (CHD). Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in human adipose tissue may be correlated with serum TG levels and help reveal novel genes involved in TG regulation. Methods Gene co-expression networks were constructed from two Finnish and one Mexican study sample using the blockwiseModules R function in Weighted Gene Co-expression Network Analysis (WGCNA). Overlap between TG-associated networks from each of the three study samples were calculated using a Fisher’s Exact test. Gene ontology was used to determine known pathways enriched in each TG-associated network. Results We measured gene expression in adipose samples from two Finnish and one Mexican study sample. In each study sample, we observed a gene co-expression network that was significantly associated with serum TG levels. The TG modules observed in Finns and Mexicans significantly overlapped and shared 34 genes. Seven of the 34 genes (ARHGAP30, CCR1, CXCL16, FERMT3, HCST, RNASET2, SELPG) were identified as the key hub genes of all three TG modules. Furthermore, two of the 34 genes (ARHGAP9, LST1) reside in previous TG GWAS regions, suggesting them as the regional candidates underlying the GWAS signals. Conclusions This study presents a novel adipose gene co-expression network with 34 genes significantly correlated with serum TG across populations.
    BMC Medical Genomics 12/2012; 5(1):61. DOI:10.1186/1755-8794-5-61 · 2.87 Impact Factor
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